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Find bus tickets from San Diego to Knoxville


San Diego-Knoxville Bus Schedule

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Journey Information

San Diego to Knoxville, TN bus - cost & duration

Cheapest price$262.30
Fastest time54h 15m
Trips per day4
Bus lines1

Frequently Asked Questions

Is it safe to travel by bus from San Diego to Knoxville right now?

We stand behind CDC guidelines that caution passengers against non-essential travel during the coronavirus outbreak. That said, we recognize not everyone is in a position to completely abstain. Whether it’s for work, to take care of family or to get back home, some circumstances inevitably require travel. If you’re one of those individuals who still needs to book a trip, you can continue to do so on Wanderu.

Know that most bus companies are still running at this time, though some have limited service. Visit our COVID-19 travel guide for resources and daily updates on the coronavirus and COVID travel restrictions.

In order to keep vehicles as clean and sanitized as possible, bus companies are taking extra precautions for coronavirus. For details on what various companies are doing to ensure their fleet remains safe for travel, click here.

How much is a bus ticket from San Diego to Knoxville?

Based on daily average prices in last 30 days, $317.00 was the low point for bus fares from San Diego to Knoxville. Buses from Knoxville to San Diego are similarly priced. Any tickets cheaper than $317.00 could be considered a great deal.

The best way to find cheap deals on bus tickets is by booking as early as possible, since most bus companies increase the price as the travel date approaches.

How long is the bus ride?

The bus usually takes around 60 hours and 45 minutes to cover the 1900 miles (3058 kilometers) from San Diego, CA to Knoxville, TN. However, the fastest bus only takes 54 hours and 15 minutes. The trip is definitely on the longer side, so plan to get comfortable on the bus. It's a good idea to bring water and snacks.

What is the busiest day of the week to travel by bus?

Thursday is usually the day of the week when buses are busiest. If you are planning to travel on a Thursday, you should make sure to book tickets well in advance as they may sell out.

On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.

When do the earliest and latest buses leave San Diego?

The first bus leaves at 1:00pm and the last bus leaves at 8:00pm. To see the times for all buses from San Diego to Knoxville, enter your specific travel dates in the search bar.

How many buses are there each day?

There are 4 scheduled buses that travel from San Diego to Knoxville every day, so you have a decent number of options to choose from. Unfortunately, none of them are direct connections, so no matter which bus you take, you will have to transfer buses at least once during your journey.

What bus companies travel from San Diego to Knoxville?

There is one bus company that operates from San Diego to Knoxville. Greyhound is the only company that connects the two cities by bus. Fortunately, it has multiple scheduled buses per day, so travelers still have a good amount of choice and flexibility.

BusDaily TripsAvg. TimeAvg. Price
Greyhound42d 12h 45m$324.57

Where does the bus leave from in San Diego?

Most buses depart from the main station in San Diego, California:

  • San Ysidro Transit Ctr
  • Bus Terminal - 1313 National Ave

Where does the bus arrive in Knoxville?

All buses from San Diego arrive at one main station in Knoxville, Tennessee:

  • Bus Terminal - 100 E Magnolia Ave

Price trends for buses from San Diego to Knoxville

Monthly average prices


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