
Coaches from Santa Cruz to Mexico City
Lowest Prices
We partner with the top coach & train carriers to bring you the best deals.
No Wanderu Fees
Without any extra fees, we make it easy to book your tickets.
Best Travel Options
We help you find & compare the best buses & trains in one place.
Journey Information
There are 6 intercity coaches per day from Santa Cruz to Mexico City. Traveling by coach from Santa Cruz to Mexico City usually takes around 57 hours, but the fastest Greyhound coach can make the trip in 52 hours and 35 minutes.
Distance | 1839 mi (2959 km) |
Shortest duration | 53h 0m |
Cheapest price | £186.33 |
Most frequent service | Greyhound |
Coach lines | 1 |
What coach companies travel from Santa Cruz to Mexico City?
On Wanderu there is one intercity coach company that operates from Santa Cruz to Mexico City. Greyhound is the only company that connects the two cities by coach available on Wanderu. Fortunately, it has multiple scheduled coaches per day for you to choose from.
Coach | Daily Trips | Avg. Time | Avg. Price |
---|---|---|---|
Greyhound | 6 | 2d 9h 18m | £189.47 |
Greyhound
Greyhound is the largest nationwide coach carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 6 bus trips from Santa Cruz to Mexico City every day, with the average journey taking around 57 hours and 18 minutes to complete. Bus tickets for Greyhound trips to Mexico City usually start from £186.
Frequently Asked Questions
Is it safe to travel by coach from Santa Cruz to Mexico City during the COVID-19 pandemic?
Our coach partners have implemented several different policies to keep you safe during the COVID-19 pandemic. From limiting vehicle capacity to enhancing cleaning protocols and upgrading air filters, coach carriers are committed to maintaining a safe environment. For details on what each company is doing to ensure their fleet remains safe for travel, click here.
In addition, federal law requires all coach passengers to wear a face covering for the entire duration of the trip. Please make sure you are wearing a face mask or you may not be allowed to board the coach.
Please visit our COVID-19 Travel Guide for more information on all carrier policies and the latest travel advisories issued by every U.S. state, Canadian province, and European country.
How long is the coach ride from Santa Cruz to Mexico City?
The coach takes an average of 57 hours to cover the 1839 miles from Santa Cruz to Mexico City. However, the fastest coach only takes 52 hours and 35 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual coach may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
What is the busiest day of the week to travel by coach?
When do the earliest and latest coaches leave Santa Cruz?
The first coach leaves at 08:00 and the last coach leaves at 23:00. To see the times for all coaches from Santa Cruz to Mexico City, enter your specific travel dates in the search bar.
How many coaches are there each day?
City Information
Mexico City



Mexico City is one of the most vibrant and liveliest cities in the world, making it an exciting destination for all travelers. One of the must-see attractions in the city is the famous Museo Nacional de Antropología, which features an extensive collection from the city’s pre-Columbian era. Its star attraction is the famous Aztec Calendar Stone, also known as Piedra del Sol. For those who enjoy exploring the city’s amazing cultural life, the Palacio de Bellas Artes is a must-see destination. The art deco-style palace hosts some of the grandest cultural events around, including concerts, operas, etc. Another unique destination to check out is Teotihuacán, a world heritage site that contains some of the largest pre-Columbian pyramids in Mexico.
Mexico City’s food scene is so vast that it can be quite hard to fully explore in just a few days. Some notable foodie destinations include Pujol, Contramar, and Quintonil. If you want to grab one of those famous Mexican churros, head over to Churreria El Moro.
Mexico City’s four major bus stations are North, South, Observatorio, and TAPO. Some intercity buses leave directly from the Mexico City International Airport, which is located just about 7 miles east of the city center.
Station Information
Where does the coach leave from in Santa Cruz?
Main departure station: Metro Center - 920 Pacific Ave
Most coaches depart from the main station in Santa Cruz.
All coach stations in Santa Cruz:
Metro Center - 920 Pacific Ave
Where does the coach arrive in Mexico City?

Image credit: Juan Carlos Fonseca Mata
Link to image attributionMain arrival station: Eje Ctrl Lazaro Cardenas
All coaches from Santa Cruz arrive at one main station in Mexico City.
Coach stations in Mexico City:
Eje Ctrl Lazaro Cardenas

Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free and with no additional fees. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.
Book coaches and trains on the go with the Wanderu app.
Download our app and snag the best travel deals across North America & Europe.Learn more
- Coach Tickets
- Mexico
- Ciudad de México
- Mexico City
- Santa Cruz to Mexico City