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Santa Cruz to Mexico City bus

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Santa Cruz - Mexico City Bus Timetable

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Journey Information

There is one daily bus from Santa Cruz to Mexico City. Traveling by bus from Santa Cruz to Mexico City usually takes around 63 hours and 39 minutes, but some buses might arrive slightly earlier or later than scheduled depending on traffic conditions.

Distance1838 mi (2958 km)
Shortest duration63h 39m
Cheapest price€333.93
Most frequent serviceFlixBus US
Bus lines1

What bus companies travel from Santa Cruz to Mexico City?

There is one intercity bus company available to search and book on Wanderu that operates from Santa Cruz to Mexico City. FlixBus US is the only company that has bus schedules available to search and book at the moment. It only makes the trip once a day on most days.

BusDaily TripsAvg. TimeAvg. Price
FlixBus US12d 15h 39m€333.93
  • FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 1 trips per day from Santa Cruz to Mexico City, and the average ticket for this route costs only .

Frequently Asked Questions

The bus takes an average of 63 hours and 39 minutes to cover the 2958 kilometers from Santa Cruz to Mexico City. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.

The busiest and least busy days to travel on this route tend to change frequently from week to week. Weather, holidays, local events, and other factors can affect how crowded the bus is on any given day.

There is usually only one bus per day from Santa Cruz to Mexico City. It leaves the station in Santa Cruz at 05:00 each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.

There is usually only one bus per day from Santa Cruz to Mexico City. However, it is not a direct bus, so you will have to get off your original vehicle to change buses during the trip.

City Information

Mexico City

Mexico City is one of the most vibrant and liveliest cities in the world, making it an exciting destination for all travelers. One of the must-see attractions in the city is the famous Museo Nacional de Antropología, which features an extensive collection from the city’s pre-Columbian era. Its star attraction is the famous Aztec Calendar Stone, also known as Piedra del Sol. For those who enjoy exploring the city’s amazing cultural life, the Palacio de Bellas Artes is a must-see destination. The art deco-style palace hosts some of the grandest cultural events around, including concerts, operas, etc. Another unique destination to check out is Teotihuacán, a world heritage site that contains some of the largest pre-Columbian pyramids in Mexico.

Mexico City’s food scene is so vast that it can be quite hard to fully explore in just a few days. Some notable foodie destinations include Pujol, Contramar, and Quintonil. If you want to grab one of those famous Mexican churros, head over to Churreria El Moro.

Mexico City’s four major bus stations are North, South, Observatorio, and TAPO. Some intercity buses leave directly from the Mexico City International Airport, which is located just about 7 miles east of the city center.

Station Information

Where does the bus leave from in Santa Cruz?

Main departure station: Metro Center - 920 Pacific Ave

Most buses depart from the main station in Santa Cruz.

All bus stations in Santa Cruz:

  • Metro Center - 920 Pacific Ave

Where does the bus arrive in Mexico City?

Eje Ctrl Lazaro Cardenas  - MXMEXGLI-0

Image credit: Juan Carlos Fonseca Mata

Link to image attribution

Main arrival station: Eje Ctrl Lazaro Cardenas

All buses from Santa Cruz arrive at one main station in Mexico City.

Bus stations in Mexico City:

  • Eje Ctrl Lazaro Cardenas

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