Cheap bus tickets from Lyon to Brussels
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Lyon to Brussels Bus Schedule
Bus from Lyon to Brussels: Journey Information
There is one daily bus from Lyon to Brussels. Traveling by bus from Lyon to Brussels usually takes around 10 hours and 45 minutes, but some buses might arrive slightly earlier or later than scheduled depending on traffic conditions.
| Distance | 352 mi (567 km) |
| Shortest duration | 10h 45m |
| Cheapest price | NOK 442.62 |
| Trips per day | 1 |
| Most frequent service | FlixBus |
| Bus lines | 1 |

What bus companies travel from Lyon to Brussels?
There is one intercity bus company available to search and book on Wanderu that operates from Lyon to Brussels. FlixBus is the only company that has bus schedules available to search and book at the moment. It only makes the trip once a day on most days.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus | 1 | 10h 45m | NOK 442.62 |
First launched in Germany in 2013, FlixBus has become one of the largest intercity bus companies in Europe. Its fleet travels through nearly every country in Europe, including the U.K. FlixBus operates an average of 1 trips from Lyon to Brussels, and usually makes the trip in about 10 hours and 45 minutes. On your trip, you'll enjoy Wi-Fi and live GPS, as well as restrooms, air conditioning, and power outlets.
Frequently asked questions about traveling by bus from Lyon to Brussels
The bus takes an average of 10 hours and 45 minutes to cover the 352 miles from Lyon to Brussels. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
There is usually only one bus per day from Lyon to Brussels. It leaves the station in Lyon at 9:00pm each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.
City Information
Lyon

Image credit: Unsplash

Image credit: Unsplash

Image credit: Unsplash
Located at the confluence of the Rhône and the Saône rivers in the central-west of France, Lyon is France's third-largest city, after Paris and Marseille. Lyon has been named a UNESCO World Heritage Site due to its 2,000 years of history and its central role in the Renaissance. Vieux Lyon is the city's historic area, full of old buildings and a vibrant French atmosphere. Wander through the traboules, a unique architectural feature of the city; these secret passageways wind through Lyon's buildings and courtyards. Several guided tours will describe the many uses of these covered paths throughout Lyon's history: from shortcuts to the river for 4th-century residents to meeting places for 19th-century silk workers and the World War II French resistance.
Lyon is also famously hailed as the birthplace of cinema. To immerse yourself in film history, visit the Musée Cinéma et Miniature to explore old movie props, costumes, and even complete film sets from several iconic films. To experience a traditional French market, stop in Les Halles de Lyon Paul Bocuse. This indoor gourmet market offers only the finest local produce, the perfect place to sample the local cuisine.
Getting to Lyon is simple, and the lion's share of options are via ground travel. Eurolines bus services offer transport from many European cities into the Perrache train station, and many train services, including the TGV, also operate from the same station. Lyon-Saint Exupéry Airport is only 25 km east of the city, providing both European and intercontinental flights.
Brussels
The center of European activities, Brussels is a cosmopolitan hub that features many cultural elements, making it one of the top destinations for international travelers. Sitting at the heart of Brussels is the famous Grand-Place, a world heritage site that boasts many nearby Gothic and Baroque architectural marvels. During the holiday season, the square hosts the Winter Wonders light show, as well as a giant Christmas tree. If you enjoy museums, don’t miss out on the Musical Instruments Museum, which is housed in an Art Nouveau building. Featuring as many as 1,200 instruments from around the world, the museum is every music fan’s dream. If you want to go on a shopping spree while in Brussels, head for the Les Galeries Royales Saint-Hubert, which is housed in a stunning Renaissance-style arcade.
Brussels is the home to many Michelin-starred restaurants, and its food scene is among the top-rated in the country. For those wishing to enjoy a contemporary twist on Belgian classics, head towards La Quincaillerie. If seafood is your go-to, Noordzee Mer du Nord will definitely satisfy your palate.
Brussels’ three main rail stations are Brussels-South, Brussels-Central, and Brussels-North, all of which are the busiest in the country. Gare du Midi, located in the Brussels-South station, is the main hub for bus travel in and out of Brussels. The city is served by several airports, the most prominent of which is the Brussels-National Airport, located 10 miles east of the city.
Station Information
Where does the bus leave from in Lyon?
Main departure station: Lyon Lyon Perrache Bus Station
Most buses depart from the main station in Lyon.
All bus stations in Lyon:
Lyon Lyon Perrache Bus Station
Where does the bus arrive in Brussels?
Main arrival station: Gare du Midi
Also known as Brussels-South railway station, the Gare du Midi is the primary train station serving Brussels. The station is technically located in Saint-Gilles, a city south of Brussels, but the Gare du Midi metro stop connects travelers to all of Brussels' sights and attractions. Many high-speed train services, including international train lines, run through the Gare du Midi. Brussels is connected to the famous Eurostar line through this station, along with Thalys and Deutsche Bahn lines. The large indoor station includes many retail shops, restaurants, and services like information desks and restrooms.
All bus stations in Brussels:
Gare du Midi
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