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Amtrak operates, on average, 1 train schedule(s) from Syracuse to Frederick. The average Amtrak ticket to Frederick costs $172.00. Cheap Amtrak tickets to Frederick are available on Wanderu starting from $145.00. In Syracuse, Amtrak departs from Reg Transp Ctr - 1 Walsh Cir and no other station. In Frederick, Amtrak arrives at 1341 Hughes Ford Rd and 1 other station.
An average trip on Amtrak from Syracuse to Frederick takes 11 hours and 2 minutes, while the fastest available Amtrak trip will get you to Frederick in 10 hours and 59 minutes,