Book Bus Tickets from

Buffalo to Spartanburg

Why book on Wanderu?

  • Lowest Prices
  • $0 Wanderu Fees
  • The Most Options
Wanderu is your cheap travel solution for booking Buffalo to Spartanburg bus tickets. With Wanderu you can compare all the bus schedules to Spartanburg by price, travel time, and other unique sorting capabilities. Book now, and you can get from Buffalo to Spartanburg in no time at all on bus lines that include Amtrak Train. Depart Buffalo from 75 Exchange St, Downtown Term - 181 Ellicott St, Buffalo Niagara Intl Airport and arrive in Spartanburg at 290 Magnolia St, 1402 E Main St, 3180 N Black Stack Rd. Wanderu aggregates trips from the most trusted and popular bus and train carriers in the country to bring you hundreds of options at the click of a mouse.

Our Travel Options

When reserving your trip with Wanderu, you'll find low prices on buses across the world! If you need to get to your destination in a hurry, then we have plenty of options. Reserve your seat on a train from Buffalo to Spartanburg and bypass traffic on the way to your next destination.


Amtrak is USA's premier train carrier. Serving both the coasts as well as taking travelers from east to west and back, amtrak is both a convenient and comfortable way to travel.