Cheap bus tickets from Chicago to Knoxville
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Chicago to Knoxville Bus Schedule
Bus from Chicago to Knoxville: Journey Information
There are 6 intercity buses per day from Chicago to Knoxville. Traveling by bus from Chicago to Knoxville usually takes around 19 hours and 55 minutes, but the fastest Greyhound bus can make the trip in 15 hours and 30 minutes.
| Distance | 455 mi (732 km) |
| Shortest duration | 15h 30m |
| Cheapest price | NOK 775.14 |
| Most frequent service | Greyhound |
| Bus lines | 2 |
How much is a bus ticket from Chicago to Knoxville?
Bus tickets for a trip from Chicago to Knoxville cost NOK 1,029.30 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Knoxville. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Chicago to Knoxville by travel date
If you're planning to travel by bus from Chicago to Knoxville in the next month, the average ticket price is expected to range from NOK 959 to NOK 1,775. The cheapest bus tickets available in the next few weeks are for trips departing on November 19, 2025.
If you’re looking to travel to Knoxville this week, bus tickets are available starting at NOK 990.
Monthly avg. prices
Prices as travel date approaches
To save money on bus tickets, buy them as early as possible. Bus carriers usually charge higher ticket prices the closer you book to the date of travel. Book your ticket at least 19 days in advance to save up to NOK 1,011.24.
What bus companies travel from Chicago to Knoxville?
There are two bus lines that have daily service from Chicago to Knoxville that you can compare and book on Wanderu. Of these two carriers, Greyhound usually offers more choice, with 4 scheduled trips per day.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 4 | 20h 50m | NOK 1,666.39 |
| Greyhound | 4 | 19h 48m | NOK 1,174.50 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 4 trips per day from Chicago to Knoxville, and the average ticket for this route costs only .
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 4 bus trips from Chicago to Knoxville every day, with the average journey taking around 19 hours and 48 minutes to complete. Bus tickets for Greyhound trips to Knoxville usually start from NOK 775.
Frequently asked questions about traveling by bus from Chicago to Knoxville
The bus takes an average of 19 hours and 55 minutes to cover the 455 miles from Chicago to Knoxville. However, the fastest bus only takes 15 hours and 30 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
With many people traveling in the middle of the week, Wednesday is the busiest day of the week for bus travel. If you are planning to travel on a Wednesday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.
The first bus leaves at 12:00am and the last bus leaves at 11:00pm. To see the times for all buses from Chicago to Knoxville, enter your specific travel dates in the search bar.
City Information
Chicago
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Chicago?
Image credit: Jeramey Jannene
Link to image attributionMain departure station: Bus Station - 630 W Harrison St
Buses to Knoxville leave from 3 stations in Chicago.
All bus stations in Chicago:
Bus Station - 630 W Harrison St
Dan Ryan Bus Station
Chicago Train Station Bus Stop
Where does the bus arrive in Knoxville?
Main arrival station: Knoxville Bus Station
All buses from Chicago arrive at one main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Get around town with Moovit
Need a return trip from Knoxville to Chicago?
Search Bus TicketsPlan your next adventure
More buses from Chicago
- Chicago to Aguascalientes Bus
NOK 3,024+
- Chicago to Santiago Papasquiaro Bus
NOK 3,112+
- Bus from Chicago to Celaya
NOK 2,929+
- Chicago to Ciudad Hidalgo Bus
NOK 3,066+
- Chicago to Birmingham Bus
NOK 1,197+
- Bus from Chicago to Dubuque
NOK 704+
- Bus from Chicago to Fort Wayne
NOK 459+
- Chicago to Indianapolis
NOK 444+
- Chicago to Ann Arbor
NOK 466+
- Bus from Chicago to Detroit
NOK 474+
- Bus from Chicago to Flint
NOK 557+
- Bus from Chicago to Holland
NOK 1,735+
- Bus from Chicago to Traverse City
NOK 546+
- Chicago to Minneapolis Bus
NOK 670+
- Bus from Chicago to Newark
NOK 1,372+
- Chicago to Nashville
NOK 795+
- Bus from Chicago to Madison
NOK 334+
- Chicago to Milwaukee
NOK 286+
Continue by bus from Knoxville
- Chattanooga to Atlanta Bus
NOK 291+
- Bus from Chattanooga to Knoxville
NOK 285+
- Chattanooga to Nashville
NOK 274+
- Clarksville to Nashville
NOK 144+
- Johnson City to New York
NOK 1,020+
- Bus from Knoxville to Chicago
NOK 1,275+
- Knoxville to Indianapolis
NOK 776+
- Knoxville to Charlotte Bus
NOK 928+
- Knoxville to Chattanooga Bus
NOK 275+
- Bus from Knoxville to Memphis
NOK 944+
- Knoxville to Nashville Bus
NOK 428+
- Bus from Memphis to Atlanta
NOK 792+
- Memphis to Nashville
NOK 557+
- Bus from Murfreesboro to Atlanta
NOK 398+
- Bus from Murfreesboro to Nashville
NOK 118+
- Bus from Nashville to Atlanta
NOK 435+
- Bus from Nashville to Knoxville
NOK 465+
- Nashville to Memphis Bus
NOK 510+
Check out these popular routes
- Bus from Calgary to Edmonton
NOK 215+
- Bus from Vancouver to Seattle
NOK 377+
- Toronto to Ottawa Bus
NOK 228+
- Washington D.C. to New York Bus
NOK 277+
- Boston to New York
NOK 273+
- Brooklyn to Philadelphia
NOK 89+
- Ithaca to New York Bus
NOK 477+
- Bus from New York to Montreal
NOK 890+
- Bus from New York to Washington D.C.
NOK 282+
- Bus from New York to Atlanta
NOK 1,217+
- Bus from New York to Boston
NOK 263+
- New York to Ithaca Bus
NOK 529+
- Bus from New York to Philadelphia
NOK 162+
- Bus from New York to Providence
NOK 410+
- Philadelphia to Brooklyn Bus
NOK 153+
- Bus from Philadelphia to New York
NOK 165+
- Bus from Providence to New York
NOK 374+
- Madison to Chicago Bus
NOK 373+
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.