Cheap bus tickets from Knoxville to Indianapolis
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Knoxville to Indianapolis Bus Schedule
Bus from Knoxville to Indianapolis: Journey Information
There are 3 intercity buses per day from Knoxville to Indianapolis. Traveling by bus from Knoxville to Indianapolis usually takes around 13 hours and 57 minutes, but the fastest Greyhound bus can make the trip in 10 hours and 35 minutes.
| Distance | 290 mi (467 km) |
| Shortest duration | 10h 35m |
| Cheapest price | PLN 242.76 |
| Most frequent service | Greyhound |
| Bus lines | 1 |

How much is a bus ticket from Knoxville to Indianapolis?
Bus tickets for a trip from Knoxville to Indianapolis cost PLN 274.43 on average. While it’s a bit pricey for a bus ticket, it’s still significantly more cost-effective than flying. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Monthly avg. prices
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 22 days in advance. This way, you can save up to PLN 331.02 on your bus ticket compared to booking last-minute.
What bus companies travel from Knoxville to Indianapolis?
There is one intercity bus company available to search and book on Wanderu that operates from Knoxville to Indianapolis. Greyhound connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 3 | 13h 57m | PLN 399.89 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 3 bus trips from Knoxville to Indianapolis every day, with the average journey taking around 13 hours and 57 minutes to complete. Bus tickets for Greyhound trips to Indianapolis usually start from PLN 243.
Frequently asked questions about traveling by bus from Knoxville to Indianapolis
The bus takes an average of 13 hours and 57 minutes to cover the 290 miles from Knoxville to Indianapolis. However, the fastest bus only takes 10 hours and 35 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
With many people traveling in the middle of the week, Wednesday is the busiest day of the week for bus travel. If you are planning to travel on a Wednesday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.
The first bus leaves at 6:00pm and the last bus leaves at 7:00pm. To see the times for all buses from Knoxville to Indianapolis, enter your specific travel dates in the search bar.
City Information
Indianapolis



Indianapolis, or often referred to as just Indy, is the capital and largest city in the state of Indiana. While the city attracts thousands of visitors from the area every month, it is during Memorial Day weekend that Indianapolis becomes the place to be for over 300,000 race car fans from all over the globe. The reason for that is the Indianapolis 500, an annual automobile race and the world’s largest single day sporting event, taking place at the iconic Indianapolis Motor Speedway.
If you’re not in Indianapolis for Memorial Day weekend, you can learn about the race and see a rare collection of 500 Indy race vehicles and memorabilia at the Indianapolis Motor Speedway Museum. And while you’re on a history streak, stop by at one of the many war memorials found throughout the city, like the Soldiers and Sailors monument, the World War II memorial, and the Indiana War Memorial where you must check out the Shrine Room for a stunning one-of-a-kind experience.
Over the past few years, Indianapolis has also been cultivating a vibrant restaurant scene, offering classic American dishes made with ingredients from local farmers, and a growing selection of international cuisine. If you’re a beer fan, you will be happy to know that Indianapolis has some of the highest quality breweries in the U.S.
Located in the heart of America’s Midwest, Indianapolis offers easy connections by bus and train to other Midwestern hubs like Chicago, Louisville, and Cincinnati, while the conveniently located airport connects Indy with the rest of the world.
Station Information
Where does the bus leave from in Knoxville?
Main departure station: Knoxville Bus Station
Most buses depart from the main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Where does the bus arrive in Indianapolis?

Image credit: Panoramio upload bot
Link to image attributionMain arrival station: 350 S Illinois St
Union Station at 350 S Illinois St in Indianapolis is a major train and bus station which serves the Amtrak Cardinal, and bus carriers including Greyhound, Jefferson Lines, Miller Transportation, and Burlington Trailways. The modern station is located directly south of the historic 1888 Union Station, which now houses a hotel, several restaurants, and a wedding venue. Union Station is in the Wholesale District of downtown Indianapolis, within walking distance to eateries and hotels. There is even an underground, climate-controlled walkway from the station to the nearby Indiana Convention Center and Lucas Oil Stadium, home to the Indianapolis Colts.
All bus stations in Indianapolis:
350 S Illinois St
E Washington St
Get around town with Moovit
Need a return trip from Indianapolis to Knoxville?
Search Bus TicketsPlan your next adventure
More buses from Knoxville
- Chattanooga to Atlanta Bus
PLN 103+
- Bus from Chattanooga to Knoxville
PLN 100+
- Chattanooga to Nashville
PLN 96+
- Clarksville to Nashville
PLN 57+
- Jackson to Nashville Bus
PLN 133+
- Johnson City to New York
PLN 360+
- Knoxville to Washington D.C. Bus
PLN 300+
- Knoxville to Atlanta Bus
PLN 191+
- Bus from Knoxville to Chicago
PLN 582+
- Bus from Knoxville to New York
PLN 360+
- Knoxville to Chattanooga Bus
PLN 97+
- Knoxville to Nashville Bus
PLN 180+
- Bus from Memphis to Atlanta
PLN 324+
- Memphis to Nashville
PLN 218+
- Bus from Murfreesboro to Atlanta
PLN 183+
- Bus from Murfreesboro to Nashville
PLN 59+
- Bus from Nashville to Atlanta
PLN 176+
- Nashville to Memphis Bus
PLN 200+
Continue by bus from Indianapolis
- Indianapolis to Los Angeles Bus
PLN 1,149+
- Indianapolis to Washington D.C. Bus
PLN 532+
- Indianapolis to Miami Bus
PLN 763+
- Bus from Indianapolis to Atlanta
PLN 321+
- Indianapolis to Chicago
PLN 191+
- Bus from Indianapolis to Fort Wayne
PLN 75+
- Indianapolis to Gary Bus
PLN 172+
- Indianapolis to Merrillville Bus
PLN 414+
- Indianapolis to Louisville Bus
PLN 114+
- Indianapolis to Boston Bus
PLN 769+
- Bus from Indianapolis to Ann Arbor
PLN 300+
- Bus from Indianapolis to Detroit
PLN 278+
- Indianapolis to Kansas City Bus
PLN 348+
- Indianapolis to Omaha Bus
PLN 370+
- Indianapolis to New York Bus
PLN 468+
- Indianapolis to Allentown Bus
PLN 576+
- Indianapolis to Philadelphia Bus
PLN 465+
- Bus from Indianapolis to Houston
PLN 817+
Check out these popular routes
- Bus from Calgary to Edmonton
PLN 78+
- Bus from Edmonton to Calgary
PLN 77+
- Bus from Vancouver to Seattle
PLN 133+
- Toronto to Ottawa Bus
PLN 101+
- Montreal to New York Bus
PLN 302+
- Boston to New York
PLN 121+
- Brooklyn to Washington D.C. Bus
PLN 139+
- Brooklyn to Philadelphia
PLN 31+
- Ithaca to New York Bus
PLN 253+
- Bus from New York to Montreal
PLN 304+
- Bus from New York to Boston
PLN 137+
- New York to Ithaca Bus
PLN 227+
- Bus from New York to Philadelphia
PLN 67+
- Bus from New York to Providence
PLN 156+
- Bus from Philadelphia to New York
PLN 65+
- Bus from Providence to New York
PLN 150+
- Seattle to Vancouver Bus
PLN 133+
- Madison to Chicago Bus
PLN 137+

Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.
- Bus Tickets
- United States
- Indiana
- Indianapolis
- Knoxville to Indianapolis






