Cheap bus tickets from Orlando, FL to Florence, SC
Find and compare the best ground travel options in one place.
Bus from Orlando, FL to Florence, SC: Journey Information
There are 5 intercity buses per day from Orlando, FL to Florence, SC. Travelling by bus from Orlando, FL to Florence, SC usually takes around 15 hours and 34 minutes, but the fastest FlixBus US bus can make the trip in 8 hours and 25 minutes.
- Distance
- 402 mi (647 km)
- Shortest duration
- 8h 25m
- Cheapest price
- CHF 51.76
- Trips per day
- 5
- Most frequent service
- FlixBus US
- Bus lines
- 2
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Orlando, FL to Florence, SC Bus Schedule
Is it better to travel by bus or train from Orlando, FL to Florence, SC?
There are usually 2 daily train trips available from Orlando, FL to Florence, SC.
Bus | Train | |
|---|---|---|
Avg. Price | Avg. PriceCHF 94.26Cheaper | Avg. PriceCHF 100.66 |
Daily Trips | Daily Trips5 | Daily Trips2 |
Duration | Duration15h 34m | Duration12h 53mFaster |

There are several bus options that can take you from Orlando, FL to Florence, SC:
See more detailsHow much is a bus ticket from Orlando, FL to Florence, SC?
Bus tickets for a trip from Orlando, FL to Florence, SC cost about CHF 67 when you book at the cheapest time, 23 days ahead. While it’s a bit pricey for a bus ticket, it’s still significantly more cost-effective than flying. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Orlando, FL to Florence, SC by travel date
If you're planning to travel by bus from Orlando, FL to Florence, SC in the next month, the average ticket price is expected to range from CHF 67 to CHF 114. The cheapest bus tickets available in the next few weeks are for trips departing on December 4, 2026. If you’re looking to travel to Florence, SC this week, bus tickets are available starting at CHF 74.
Average bus ticket prices from Orlando, FL to Florence, SC by month
Taking the bus from Orlando, FL to Florence, SC is usually cheapest in October, when the average ticket price is only CHF 95. If you're planning to take the bus from Orlando, FL to Florence, SC during May, keep in mind that bus ticket prices may be higher than usual, with an average price of CHF 129. However, booking your trip in advance can help you score a ticket at a better price.
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 23 days in advance. This way, you can save up to CHF 54.53 on your bus ticket compared to booking last-minute.
What bus companies travel from Orlando, FL to Florence, SC?
There are two bus lines that have daily service from Orlando, FL to Florence, SC that you can compare and book on Wanderu. Of these two carriers, FlixBus US usually offers more choice, with 5 scheduled trips per day.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 5 | 15h 34m | CHF 94.15 |
| Tornado Bus | 1 | 29h 40m | CHF 263.07 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 5 trips per day from Orlando, FL to Florence, SC, and the average ticket for this route costs only CHF 94.15.






Frequently asked questions about travelling by bus from Orlando, FL to Florence, SC
There are 5 scheduled buses that travel from Orlando, FL to Florence, SC every day, so you have a decent number of options to choose from. However, only one of these is a direct bus. With direct service, you do not have to transfer onto a different bus at any point during your trip. Direct buses also tend to be significantly faster, which is worth bearing in mind as you compare the available options. Need more travel options? Consider taking the train from Orlando, FL to Florence, SC; ticket prices start at CHF 58.
Trips per day
5
Direct trips
1
The bus takes an average of 15 hours and 34 minutes to cover the 647 kilometres from Orlando, FL to Florence, SC. However, the fastest bus only takes 8 hours and 25 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Distance (mi)
402
Distance (km)
647
The first bus leaves at 4:45 a.m. and the last bus leaves at 11:00 p.m. To see the times for all buses from Orlando, FL to Florence, SC, enter your specific travel dates in the search bar.
Earliest bus
4:45am
Latest bus
11:00pm
Sunday tends to be the busiest day for buses, as many passengers take the bus to Florence, SC at the end of the week. If you are planning to travel on a Sunday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
Most crowded
Sunday
Least crowded
Tuesday
City Information
Orlando



Orlando is the Theme Park Capital of the World, thanks to the high density of thrilling parks like Walt Disney World, Universal Studios, SeaWorld, LEGOLAND, Gatorland and more. It's no wonder we rated Orlando the #1 travel destination for families. Family vacation or not, if the highlight of your trip is picking out a wand at Ollivanders in the Wizarding World of Harry Potter or finally meeting Elsa in the Magic Kingdom, you know we won't judge.
Winter Park and Thornton Park – not more theme parks, we promise – are trendy neighbourhoods where you can experience some of Orlando's world-class shopping, dining, and craft beer. You can also immerse yourself in some of Florida's unique wildlife at Orlando Wetlands Park, or the more central Lake Eola Park downtown. Orlando enjoys an average of 233 days of sunshine a year, so even though it's one of the cheapest cities to visit over Spring Break, you'll soak up that sweet, sweet sun almost any time of year.
Craving the ocean? Head a few hours outside Orlando for some of Florida's gorgeous beaches like New Smyrna Beach, Cocoa Beach, and the Canaveral National Seashore. Two large airports, as well as many bus and train companies with service in the area, mean that travelling from Orlando to other sunny Florida destinations and beyond is a breeze.
Florence
Florence is a hidden gem in the northeast of South Carolina. Though best known for its history as a significant railway hub, Florence is a modern city with activities and sights to fill a weekend getaway or a longer vacation.
Every November, Florence goes nuts during the SC Pecan Music and Food Festival, an event hosted downtown to celebrate the beloved pecan. If you're in town during the festival, check out the car show, live music, half marathon, and other associated events to get to know Florence locals and culture.
Florence is a year-round destination for outdoor recreation. Golf is a favourite among Florence residents, so upgrade from mini-golf and try the real thing. Traces Golf Club welcomes golfers of all skill levels, don't worry. Don't leave Florence without spending a day at Lynches River County Park, the starting point of the 66-mile South Carolina Revolutionary Rivers Trail. You can kayak or canoe throughout the county, following the swampy path that allowed American patriots to evade British troops in the American Revolution.
Florence Regional Airport operates limited flights to connect to Charlotte, but most paths to Florence involve some kind of ground travel. Amtrak's Palmetto and Silver Service trains stop in Florence, with connections to New York and Washington to the north and Orlando and Miami to the south. Greyhound and Southeastern Stages offer intercity bus service to Florence that connects the city to other destinations throughout the South.
Station Information
Where does the bus leave from in Orlando, FL?
Main departure station: Orlando Bus Terminal

The Bus Terminal at 555 N John Young Pkwy is the primary Greyhound bus station in Orlando, where travellers can catch a bus to other destinations throughout Florida and beyond. The station is located under 3 miles from downtown Orlando and the nearest SunRail station. There is also a Lynx public bus stop which conveniently drops people off right at the Greyhound Bus Terminal. Open 24 hours a day, the bus station provides vending machines if you need a quick bite, and there are also several fast food options within a short walk to fuel up before your trip.
All bus stations in Orlando, FL:
- Bus Terminal - 555 N John Young Pkwy
- The Florida Mall
- Servi Florida Travel
Where does the bus arrive in Florence, SC?
Main arrival station: 611 S Irby St
Buses arrive in Florence, SC at 3 stations, depending on which bus line you are travelling with.
All bus stations in Florence, SC:
- 611 S Irby St
- 2301 W Lucas St (TA Gas Station)
- 2301 W Lucas St (TA Gas Station)
Need a return trip from Florence, SC to Orlando, FL?
Search Bus TicketsPlan your next adventure
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Continue by bus from Florence, SC
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