Cheap bus tickets from Chicago to Knoxville
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Chicago to Knoxville Bus Schedule
Bus from Chicago to Knoxville: Journey Information
There are 6 intercity buses per day from Chicago to Knoxville. Traveling by bus from Chicago to Knoxville usually takes around 19 hours and 53 minutes, but the fastest Greyhound bus can make the trip in 15 hours and 30 minutes.
| Distance | 455 mi (732 km) |
| Shortest duration | 15h 30m |
| Cheapest price | RON 334.18 |
| Most frequent service | Greyhound |
| Bus lines | 2 |
How much is a bus ticket from Chicago to Knoxville?
Bus tickets for a trip from Chicago to Knoxville cost RON 447.75 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Knoxville. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Chicago to Knoxville by travel date
If you're planning to travel by bus from Chicago to Knoxville in the next month, the average ticket price is expected to range from RON 413 to RON 770. The cheapest bus tickets available in the next few weeks are for trips departing on November 19, 2025.
If you’re looking to travel to Knoxville this week, bus tickets are available starting at RON 427.
Monthly avg. prices
Prices as travel date approaches
To save money on bus tickets, buy them as early as possible. Bus carriers usually charge higher ticket prices the closer you book to the date of travel. Book your ticket at least 14 days in advance to save up to RON 423.34.
What bus companies travel from Chicago to Knoxville?
There are two bus lines that have daily service from Chicago to Knoxville that you can compare and book on Wanderu. Of these two carriers, Greyhound usually offers more choice, with 4 scheduled trips per day.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 4 | 20h 50m | RON 718.59 |
| Greyhound | 4 | 19h 46m | RON 508.28 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 4 trips per day from Chicago to Knoxville, and the average ticket for this route costs only .
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 4 bus trips from Chicago to Knoxville every day, with the average journey taking around 19 hours and 46 minutes to complete. Bus tickets for Greyhound trips to Knoxville usually start from RON 334.
Frequently asked questions about traveling by bus from Chicago to Knoxville
The bus takes an average of 19 hours and 53 minutes to cover the 455 miles from Chicago to Knoxville. However, the fastest bus only takes 15 hours and 30 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Saturday is usually the day when buses are busiest, as many travelers take the bus to enjoy the weekend in Knoxville. If you are planning to travel on a Saturday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Wednesday is typically the least busy day for bus travel on this route. If you're looking for some extra space on the bus, traveling mid-week is your best bet.
The first bus leaves at 12:00am and the last bus leaves at 11:00pm. To see the times for all buses from Chicago to Knoxville, enter your specific travel dates in the search bar.
City Information
Chicago
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Chicago?
Image credit: Jeramey Jannene
Link to image attributionMain departure station: Bus Station - 630 W Harrison St
Buses to Knoxville leave from 3 stations in Chicago.
All bus stations in Chicago:
Bus Station - 630 W Harrison St
Dan Ryan Bus Station
Chicago Train Station Bus Stop
Where does the bus arrive in Knoxville?
Main arrival station: Knoxville Bus Station
All buses from Chicago arrive at one main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Get around town with Moovit
Need a return trip from Knoxville to Chicago?
Search Bus TicketsPlan your next adventure
More buses from Chicago
- Chicago to Aguascalientes Bus
RON 1,304+
- Chicago to Santiago Papasquiaro Bus
RON 1,342+
- Bus from Chicago to Celaya
RON 1,263+
- Chicago to Ciudad Hidalgo Bus
RON 1,322+
- Chicago to Birmingham Bus
RON 516+
- Bus from Chicago to Dubuque
RON 304+
- Bus from Chicago to Fort Wayne
RON 198+
- Chicago to Indianapolis
RON 192+
- Chicago to Ann Arbor
RON 201+
- Bus from Chicago to Detroit
RON 204+
- Bus from Chicago to Flint
RON 240+
- Bus from Chicago to Holland
RON 748+
- Bus from Chicago to Traverse City
RON 235+
- Chicago to Minneapolis Bus
RON 289+
- Bus from Chicago to Newark
RON 591+
- Chicago to Nashville
RON 343+
- Bus from Chicago to Madison
RON 144+
- Chicago to Milwaukee
RON 123+
Continue by bus from Knoxville
- Chattanooga to Atlanta Bus
RON 125+
- Bus from Chattanooga to Knoxville
RON 123+
- Chattanooga to Nashville
RON 118+
- Clarksville to Nashville
RON 62+
- Johnson City to New York
RON 440+
- Bus from Knoxville to Chicago
RON 550+
- Knoxville to Indianapolis
RON 335+
- Knoxville to Charlotte Bus
RON 400+
- Knoxville to Chattanooga Bus
RON 119+
- Bus from Knoxville to Memphis
RON 407+
- Knoxville to Nashville Bus
RON 185+
- Bus from Memphis to Atlanta
RON 342+
- Memphis to Nashville
RON 240+
- Bus from Murfreesboro to Atlanta
RON 171+
- Bus from Murfreesboro to Nashville
RON 51+
- Bus from Nashville to Atlanta
RON 188+
- Bus from Nashville to Knoxville
RON 200+
- Nashville to Memphis Bus
RON 220+
Check out these popular routes
- Bus from Calgary to Edmonton
RON 93+
- Bus from Vancouver to Seattle
RON 163+
- Toronto to Ottawa Bus
RON 98+
- Washington D.C. to New York Bus
RON 120+
- Boston to New York
RON 118+
- Brooklyn to Philadelphia
RON 38+
- Ithaca to New York Bus
RON 206+
- Bus from New York to Montreal
RON 384+
- Bus from New York to Washington D.C.
RON 121+
- Bus from New York to Atlanta
RON 525+
- Bus from New York to Boston
RON 113+
- New York to Ithaca Bus
RON 228+
- Bus from New York to Philadelphia
RON 70+
- Bus from New York to Providence
RON 177+
- Philadelphia to Brooklyn Bus
RON 66+
- Bus from Philadelphia to New York
RON 71+
- Bus from Providence to New York
RON 161+
- Madison to Chicago Bus
RON 161+
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.