Cheap bus tickets from Lafayette, IN to St Louis, MO
Find and compare the best ground travel options in one place.
Bus from Lafayette, IN to St Louis, MO: Journey Information
There are 3 intercity buses per day from Lafayette, IN to St Louis, MO. Traveling by bus from Lafayette, IN to St Louis, MO usually takes around 9 hours and 51 minutes, but the fastest Greyhound bus can make the trip in 7 hours and 15 minutes.
| Distance | 216 mi (348 km) |
| Shortest duration | 7h 15m |
| Cheapest price | $42.47 |
| Trips per day | 0 |
| Most frequent service | Greyhound |
| Bus lines | 1 |
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Lafayette to St Louis Bus Schedule

There are several bus options that can take you from Lafayette to St Louis:
See more detailsHow much is a bus ticket from Lafayette, IN to St Louis, MO?
Bus tickets for a trip from Lafayette, IN to St Louis, MO cost $57.87 on average. Tickets cheaper than $57.87 are an excellent bargain. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Lafayette, IN to St Louis, MO by travel date
If you're planning to travel by bus from Lafayette, IN to St Louis, MO in the next month, the average ticket price is expected to range from $44 to $60. The cheapest bus tickets available in the next few weeks are for trips departing on August 26, 2026. If you’re looking to travel to St Louis, MO this week, bus tickets are available starting at $44.
Average bus ticket prices from Lafayette, IN to St Louis, MO by month
Taking the bus from Lafayette, IN to St Louis, MO is usually cheapest in February, when the average ticket price is only $47. If you're planning to take the bus from Lafayette, IN to St Louis, MO during March, keep in mind that bus ticket prices may be higher than usual, with an average price of $65. However, booking your trip in advance can help you score a ticket at a better price.
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 8 days in advance. This way, you can save up to $40.81 on your bus ticket compared to booking last-minute.
What bus companies travel from Lafayette to St Louis?
There are multiple buses that travel from Lafayette to St Louis, including Greyhound. Here is what you should know about the 1 most popular bus lines:
| BUS | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 3 | 9h 51m | $69.89 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 3 bus trips from Lafayette, IN to St Louis, MO every day, with the average journey taking around 9 hours and 51 minutes to complete. Bus tickets for Greyhound trips to St Louis, MO usually start from $42.47.






Frequently asked questions about traveling by bus from Lafayette to St Louis
There are 3 scheduled buses that travel from Lafayette, IN to St Louis, MO every day, so you have a decent number of options to choose from. Unfortunately, none of them are direct connections, so no matter which bus you take, you will have to transfer buses at least once during your journey. Need more travel options? Consider taking the train from Lafayette, IN to St Louis, MO; ticket prices start at $110.
TRIPS PER DAY
3
DIRECT TRIPS
0
The bus takes an average of 9 hours and 51 minutes to cover the 216 miles from Lafayette, IN to St Louis, MO. However, the fastest bus only takes 7 hours and 15 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
DISTANCE (MI)
216
DISTANCE (KM)
348
The first bus leaves at 6:40am and the last bus leaves at 7:05pm. To see the times for all buses from Lafayette, IN to St Louis, MO, enter your specific travel dates in the search bar.
EARLIEST BUS
6:40am
LATEST BUS
7:05pm
Sunday tends to be the busiest day for buses, as many passengers take the bus to St Louis, MO at the end of the week. If you are planning to travel on a Sunday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Monday is typically the least busy day for bus travel on this route. For a less crowded trip, try to book your bus travel for the beginning of the week.
MOST CROWDED
Sunday
LEAST CROWDED
Monday
City Information
Lafayette, IN



Lafayette, a quaint college town with a vibrant history, is a superb destination for fans of history and old buildings. The city's historic old quarter is a beautiful sight to behold, with some buildings dating back to the 19th century. A walk around this quarter will bring you back to the early days of the American Industrial Revolution. Don't miss out on the chance to visit Fort Ouiatenon, the first European fortified settlement in the area now called Indiana. If you are looking for a spot to enjoy a picnic with your friends and your family, head to historic Prophetstown State Park for plenty of activities; we're talking a water park, unique wildlife observation, camping, and a working farm dating back to the 1920s.
Lafayette's food scene offers a good mix of traditional dishes and modern ones. If you wish to enjoy genuine local specialties, South Street Smokehouse offers amazing homestyle dishes. For those who just can't have enough local pizzas, stop by Arni's, a pizzeria that has been around for more than 40 years.
Travel to Lafayette is easy thanks to multiple bus lines and the Amtrak Cardinal line, which runs through the city. The nearest major airport is about 60 miles away in Indianapolis, so ground travel is definitely your friend for this destination.
St Louis, MO



St. Louis is one of several major cities in the state of Missouri and it is uniquely located near the confluence of the Mississippi and Missouri rivers. The city is usually recognized by its most distinctive feature, the Gateway Arch, thanks to which it is the only city in the United States that has a national park in the heart of its downtown district. The Arch is a must-see attraction and you can even take a tram to the top for some incredible views of the St. Louis skyline.
Some of the other truly unique attractions you can visit while you’re in town include the Miniature Museum of Greater St. Louis where you can check out an incredible collection of dolls, dollhouses and vignettes, and the City Museum where you can ride down a 10-story spiral slide (yup, you read that right.) For a great outdoor experience, stop by the gorgeous Missouri Botanical Garden, and then take a stroll through Citygarden where you will find various quirky statues and installations worthy of being featured in your Instagram feed.
Ale enthusiasts would be excited to know that St. Louis is one of the best craft beer cities in the U.S. as well as one of the cheapest drinking cities. That means your party budget could take you a long way. Unsurprisingly, the city is also among the best spring break destinations on a budget.
The main bus and train station in St. Louis, Gateway Station, is located right in the center of downtown, not far from the Gateway Arch, which makes coming in and out of the city a breeze.
Station Information
Where does the bus leave from in Lafayette?
Main departure station: Parking Lot next to CityBus Center
Most buses depart from the main station in Lafayette, IN.
All bus stations in Lafayette:
- Parking Lot next to CityBus Center
Where does the bus arrive in St Louis?
Main arrival station: Gateway Station - 430 S 15th St
All buses from Lafayette, IN arrive at one main station in St Louis, MO.
All bus stations in St Louis:
- Gateway Station - 430 S 15th St
Need a return trip from St Louis to Lafayette?
Search Bus Tickets
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu's simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.




