Cheap bus tickets from Greenville, SC to Chicago, IL

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Bus from Greenville, SC to Chicago, IL: Journey Information

There are 2 intercity buses per day from Greenville, SC to Chicago, IL. Traveling by bus from Greenville, SC to Chicago, IL usually takes around 1 day, 5 hours, and 48 minutes, but the fastest FlixBus US bus can make the trip in 19 hours and 40 minutes.

Distance: 562 mi (904 km)
Shortest duration: 19h 40m
Cheapest price: SEK 1,330.72
Trips per day: 1
Most frequent service: FlixBus US
Bus lines: 2

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Greenville, SC to Chicago, IL Bus Schedule

No preview is currently available. Please try another date or search the full schedule.

There are several bus options that can take you from Greenville, SC to Chicago, IL:

See more details

How much is a bus ticket from Greenville, SC to Chicago, IL?

Bus tickets for a trip from Greenville, SC to Chicago, IL cost SEK 2,061 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Chicago, IL. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.

Average bus ticket prices from Greenville, SC to Chicago, IL by travel date

If you're planning to travel by bus from Greenville, SC to Chicago, IL in the next month, the average ticket price is expected to range from SEK 864 to SEK 4,077. The cheapest bus tickets available in the next few weeks are for trips departing on November 5, 2026. If you’re looking to travel to Chicago, IL this week, bus tickets are available starting at SEK 1,267.

Average bus ticket prices from Greenville, SC to Chicago, IL by month

Taking the bus from Greenville, SC to Chicago, IL is usually cheapest in September, when the average ticket price is only SEK 1,650. If you're planning to take the bus from Greenville, SC to Chicago, IL during February, keep in mind that bus ticket prices may be higher than usual, with an average price of SEK 2,181. However, booking your trip in advance can help you score a ticket at a better price.

Prices as travel date approaches

Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. Booking in advance, even by a couple of days, is the best way to find cheaper bus tickets.

What bus companies travel from Greenville, SC to Chicago, IL?

There are two bus lines that have daily service from Greenville, SC to Chicago, IL that you can compare and book on Wanderu. Of these two carriers, FlixBus US usually offers more choice, with 5 scheduled trips per day.

Bus	Daily Trips	Avg. Time	Avg. Price
FlixBus US	5	24h 26m	SEK 1,985.19
Tornado Bus	1	45h 53m	SEK 3,992.64

FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 5 trips per day from Greenville, SC to Chicago, IL, and the average ticket for this route costs only SEK 1,985.19.
Tornado Bus is a Texan bus company operating in Texas and Mexico. Their bus service connects cities such as Houston, McAllen, San Antonio, and the international border at El Paso. Their buses offer onboard WiFi, plenty of leg room, air conditioning, restrooms, and power outlets.

Frequently asked questions about traveling by bus from Greenville, SC to Chicago, IL

There are usually only 2 buses per day from Greenville, SC to Chicago, IL. One bus is a direct connection, meaning that you can stay on the same vehicle for the entire trip, without having to transfer onto a connecting bus at any point. Need more travel options? Consider taking the train from Greenville, SC to Chicago, IL; ticket prices start at SEK 1,788.

Trips per day

Direct trips

The bus takes an average of 1 day, 5 hours, and 48 minutes to cover the 562 miles from Greenville, SC to Chicago, IL. However, the fastest bus only takes 19 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.

Distance (mi)

562

Distance (km)

904

The first bus leaves at 1:20 PM and the last bus leaves at 9:35 PM. To see the times for all buses from Greenville, SC to Chicago, IL, enter your specific travel dates in the search bar.

Earliest bus

1:20pm

Latest bus

9:35pm

Tuesday is usually the day of the week when buses are busiest. If you are planning to travel on a Tuesday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Monday is typically the least busy day for bus travel on this route. For a less crowded trip, try to book your bus travel for the beginning of the week.

Most crowded

Tuesday

Least crowded

Monday

City Information

Greenville

As the sixth-largest city in the state of South Carolina, Greenville is one of the state's hidden treasures! The city is a vibrant hub of artistic activities and exhibitions, with many on display at the Greenville County Museum of Art. For fans of automobiles, especially BMW cars, the BMW Zentrum will offer a comprehensive look at the brand's past, present, and future. To get close to nature, check out Cedar Falls Park, which features a majestic 200-foot wide waterfall as well as plenty of other scenic spots.

The city of Greenville boasts a vibrant food scene with plenty of signature Southern dishes. One of the best places in town to enjoy an authentic Southern BBQ dinner is at Bacon Bros. Public House, which offers impressive dishes at very affordable prices. For a more upscale dining experience, check out Passerelle Bistro, where you can have some of the finest French dishes.

Greenville is well-connected by both buses and trains, with frequent service to destinations like Orlando, New Orleans, Richmond, and even New York. Plus, the Greenville-Spartanburg International Airport is only 15 minutes from downtown Greenville.

Chicago

Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.

You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.

Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.

Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.

Station Information

Where does the bus leave from in Greenville, SC?

Main departure station: 1116 Woodruff Rd

Greenville, SC has two bus stations with service to Chicago, IL.

All bus stations in Greenville, SC:

1116 Woodruff Rd
2803 White Horse Rd

Where does the bus arrive in Chicago, IL?

Main arrival station: 3501 S California Ave

Buses arrive in Chicago, IL at 4 stations, depending on which bus line you are traveling with.

All bus stations in Chicago, IL:

3501 S California Ave
Bus Station - 630 W Harrison St
Chicago Train Station Bus Stop
Dan Ryan Bus Station

Need a return trip from Chicago, IL to Greenville, SC?

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