Cheap bus tickets from Knoxville to Chicago
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Knoxville to Chicago Bus Schedule
Bus from Knoxville to Chicago: Journey Information
There are 7 intercity buses per day from Knoxville to Chicago. Traveling by bus from Knoxville to Chicago usually takes around 17 hours and 13 minutes, but the fastest Greyhound bus can make the trip in 14 hours and 40 minutes.
| Distance | 455 mi (732 km) |
| Shortest duration | 14h 40m |
| Cheapest price | HRK 386.15 |
| Most frequent service | Greyhound |
| Bus lines | 1 |
How much is a bus ticket from Knoxville to Chicago?
Bus tickets for a trip from Knoxville to Chicago cost HRK 753.51 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Chicago. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Knoxville to Chicago by travel date
Over the next four weeks, the average price of bus tickets from Knoxville to Chicago is expected to be between HRK 694 and HRK 1,054. The cheapest day to travel in the next month is November 11, 2025, when tickets are available for November 11, 2025. The cheapest bus tickets available in the next week start at just HRK 694.
Monthly avg. prices
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 19 days in advance. This way, you can save up to HRK 535.85 on your bus ticket compared to booking last-minute.
What bus companies travel from Knoxville to Chicago?
There is one intercity bus company available to search and book on Wanderu that operates from Knoxville to Chicago. Greyhound connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 7 | 17h 14m | HRK 822.01 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 7 bus trips from Knoxville to Chicago every day, with the average journey taking around 17 hours and 14 minutes to complete. Bus tickets for Greyhound trips to Chicago usually start from HRK 386.
Frequently asked questions about traveling by bus from Knoxville to Chicago
The bus takes an average of 17 hours and 13 minutes to cover the 455 miles from Knoxville to Chicago. However, the fastest bus only takes 14 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Thursday is usually the day of the week when buses are busiest. If you are planning to travel on a Thursday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
The first bus leaves at 6:00pm and the last bus leaves at 10:00pm. To see the times for all buses from Knoxville to Chicago, enter your specific travel dates in the search bar.
City Information
Chicago
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Knoxville?
Main departure station: Knoxville Bus Station
Most buses depart from the main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Where does the bus arrive in Chicago?
Image credit: Jeramey Jannene
Link to image attributionMain arrival station: Bus Station - 630 W Harrison St
Buses arrive in Chicago at 3 stations, depending on which bus line you are traveling with.
All bus stations in Chicago:
Bus Station - 630 W Harrison St
Dan Ryan Bus Station
Chicago Train Station Bus Stop
Get around town with Moovit
Need a return trip from Chicago to Knoxville?
Search Bus TicketsPlan your next adventure
More buses from Knoxville
- Chattanooga to Atlanta Bus
HRK 187+
- Bus from Chattanooga to Knoxville
HRK 183+
- Chattanooga to Nashville
HRK 176+
- Clarksville to Nashville
HRK 90+
- Jackson to Nashville Bus
HRK 218+
- Johnson City to New York
HRK 655+
- Knoxville to Atlanta Bus
HRK 286+
- Knoxville to Charlotte Bus
HRK 579+
- Bus from Knoxville to New York
HRK 655+
- Knoxville to Chattanooga Bus
HRK 177+
- Bus from Knoxville to Memphis
HRK 579+
- Knoxville to Nashville Bus
HRK 276+
- Bus from Memphis to Atlanta
HRK 506+
- Memphis to Nashville
HRK 361+
- Bus from Murfreesboro to Atlanta
HRK 248+
- Bus from Murfreesboro to Nashville
HRK 69+
- Bus from Nashville to Atlanta
HRK 280+
- Nashville to Memphis Bus
HRK 325+
Continue by bus from Chicago
- Bus from Chicago to Celaya
HRK 1,881+
- Chicago to Birmingham Bus
HRK 744+
- Bus from Chicago to Goshen
HRK 229+
- Chicago to Indianapolis
HRK 285+
- Bus from Chicago to New Orleans
HRK 982+
- Bus from Chicago to Detroit
HRK 299+
- Bus from Chicago to Flint
HRK 346+
- Bus from Chicago to Traverse City
HRK 350+
- Chicago to Minneapolis Bus
HRK 428+
- Bus from Chicago to St Louis
HRK 365+
- Bus from Chicago to Omaha
HRK 645+
- Bus from Chicago to Akron
HRK 411+
- Chicago to Oklahoma City Bus
HRK 1,195+
- Chicago to Richmond
HRK 1,099+
- Chicago to Milwaukee
HRK 187+
- Bus from Chicago to Wausau
HRK 218+
- Chicago to Charleston Bus
HRK 537+
Check out these popular routes
- Bus from Calgary to Edmonton
HRK 141+
- Bus from Vancouver to Seattle
HRK 242+
- Toronto to Ottawa Bus
HRK 207+
- Montreal to New York Bus
HRK 544+
- Bus from Atlanta to New York
HRK 827+
- Boston to New York
HRK 175+
- Brooklyn to Washington D.C. Bus
HRK 253+
- Ithaca to New York Bus
HRK 313+
- Bus from New York to Montreal
HRK 570+
- Bus from New York to Washington D.C.
HRK 169+
- Bus from New York to Boston
HRK 169+
- New York to Ithaca Bus
HRK 301+
- Bus from New York to Philadelphia
HRK 105+
- Philadelphia to Brooklyn Bus
HRK 98+
- Bus from Philadelphia to New York
HRK 106+
- Dallas to Houston Bus
HRK 260+
- Houston to Dallas Bus
HRK 236+
- Madison to Chicago Bus
HRK 241+
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.