Cheap bus tickets from St Louis to Chicago
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Bus from St Louis to Chicago: Journey Information
There are 8 intercity buses per day from St Louis to Chicago. Travelling by bus from St Louis to Chicago usually takes around 8 hours and 6 minutes, but the fastest FlixBus US bus can make the trip in 5 hours and 40 minutes.
- Distance
- 262 mi (422 km)
- Shortest duration
- 5h 40m
- Cheapest price
- CHF 27.13
- Trips per day
- 8
- Most frequent service
- FlixBus US
- Bus lines
- 2
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St Louis to Chicago Bus Schedule
Is it better to travel by bus or train from St Louis to Chicago?
There are usually 6 daily train trips available from St Louis to Chicago.
Bus | Train | |
|---|---|---|
Avg. Price | Avg. PriceCHF 58.50Cheaper | Avg. PriceCHF 80.17 |
Daily Trips | Daily Trips8 | Daily Trips6 |
Duration | Duration8h 6m | Duration5h 55mFaster |

Bus Trip Reviews from Wanderu Customers
Average score for buses from St Louis to Chicago (Based on 11 ratings and reviews)
4.0
1.0
St Louis to Chicago Route Map

There are several bus options that can take you from St Louis to Chicago:
See more detailsHow much is a bus ticket from St Louis to Chicago?
Bus tickets for a trip from St Louis to Chicago cost about CHF 48 when you book at the cheapest time, 29 days ahead. Tickets cheaper than CHF 48 are an excellent bargain. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from St Louis to Chicago by travel date
If you're planning to travel by bus from St Louis to Chicago in the next month, the average ticket price is expected to range from CHF 35 to CHF 83. The cheapest bus tickets available in the next few weeks are for trips departing on December 7, 2026. If you’re looking to travel to Chicago this week, bus tickets are available starting at CHF 39.
Average bus ticket prices from St Louis to Chicago by month
Taking the bus from St Louis to Chicago is usually cheapest in January, when the average ticket price is only CHF 44. If you're planning to take the bus from St Louis to Chicago during June, keep in mind that bus ticket prices may be higher than usual, with an average price of CHF 57. However, booking your trip in advance can help you score a ticket at a better price.
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 29 days in advance. This way, you can save up to CHF 27 on your bus ticket compared to booking last-minute.
What bus companies travel from St Louis to Chicago?
There are two bus lines that have daily service from St Louis to Chicago that you can compare and book on Wanderu. Of these two carriers, FlixBus US usually offers more choice, with 5 scheduled trips per day.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 5 | 6h 44m | CHF 53.84 |
| Greyhound | 3 | 11h 43m | CHF 70.87 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 5 trips per day from St Louis to Chicago, and the average ticket for this route costs only CHF 53.84.






Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 3 bus trips from St Louis to Chicago every day, with the average journey taking around 11 hours and 43 minutes to complete. Bus tickets for Greyhound trips to Chicago usually start from CHF 38.39.






Frequently asked questions about travelling by bus from St Louis to Chicago
There are 8 scheduled buses that travel from St Louis to Chicago every day, so you have a decent number of options to choose from. This includes 3 direct buses, where you can stay on the same bus without having to transfer to a connecting bus at any point during your trip. Need more travel options? Consider taking the train from St Louis to Chicago; ticket prices start at CHF 26.
Trips per day
8
Direct trips
3
The bus takes an average of 8 hours and 6 minutes to cover the 422 kilometres from St Louis to Chicago. However, the fastest bus only takes 5 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Distance (mi)
262
Distance (km)
422
The first bus leaves at 2:00 a.m. and the last bus leaves at 11:30 p.m. To see the times for all buses from St Louis to Chicago, enter your specific travel dates in the search bar.
Earliest bus
2:00am
Latest bus
11:30pm
Friday is the busiest travel day for buses as people head from St Louis to Chicago for the weekend. If you are planning to travel on a Friday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
Most crowded
Friday
Least crowded
Tuesday
City Information
St Louis



St. Louis is one of several major cities in the state of Missouri and it is uniquely located near the confluence of the Mississippi and Missouri rivers. The city is usually recognized by its most distinctive feature, the Gateway Arch, thanks to which it is the only city in the United States that has a national park in the heart of its downtown district. The Arch is a must-see attraction and you can even take a tram to the top for some incredible views of the St. Louis skyline.
Some of the other truly unique attractions you can visit while you’re in town include the Miniature Museum of Greater St. Louis where you can check out an incredible collection of dolls, dollhouses and vignettes, and the City Museum where you can ride down a 10-story spiral slide (yup, you read that right.) For a great outdoor experience, stop by the gorgeous Missouri Botanical Garden, and then take a stroll through Citygarden where you will find various quirky statues and installations worthy of being featured in your Instagram feed.
Ale enthusiasts would be excited to know that St. Louis is one of the best craft beer cities in the U.S. as well as one of the cheapest drinking cities. That means your party budget could take you a long way. Unsurprisingly, the city is also among the best spring break destinations on a budget.
The main bus and train station in St. Louis, Gateway Station, is located right in the centre of downtown, not far from the Gateway Arch, which makes coming in and out of the city a breeze.
Chicago



Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighbourhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theatre, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in St Louis?
Main departure station: Gateway Station - 430 S 15th St
Most buses depart from the main station in St Louis.
All bus stations in St Louis:
- Gateway Station - 430 S 15th St
Where does the bus arrive in Chicago?
Main arrival station: Bus Station - 630 W Harrison St

Buses arrive in Chicago at 3 stations, depending on which bus line you are travelling with.
All bus stations in Chicago:
- Bus Station - 630 W Harrison St
- Dan Ryan Bus Station
- Chicago Train Station Bus Stop
Need a return trip from Chicago to St Louis?
Search Bus TicketsPlan your next adventure
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