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Cheap bus tickets from Cleveland, OH to Knoxville, TN

Find and compare the best ground travel options in one place.

Bus from Cleveland, OH to Knoxville, TN: Journey Information

There are 2 intercity buses per day from Cleveland, OH to Knoxville, TN. Traveling by bus from Cleveland, OH to Knoxville, TN usually takes around 21 hours and 44 minutes, but the fastest Greyhound bus can make the trip in 15 hours and 25 minutes.

Distance
401 mi (645 km)
Shortest duration
15h 25m
Cheapest price
CZK 1,622.75
Trips per day
0
Most frequent service
Greyhound
Bus lines
1

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Cleveland, OH to Knoxville, TN Bus Schedule

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There are several bus options that can take you from Cleveland, OH to Knoxville, TN:

See more details

How much is a bus ticket from Cleveland, OH to Knoxville, TN?

Bus tickets for a trip from Cleveland, OH to Knoxville, TN cost CZK 1,633 on average. While it’s a bit pricey for a bus ticket, it’s still significantly more cost-effective than flying. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.

Average bus ticket prices from Cleveland, OH to Knoxville, TN by travel date

CZK 2,475CZK 1,650CZK 825OctOct

If you're planning to travel by bus from Cleveland, OH to Knoxville, TN in the next month, the average ticket price is expected to range from CZK 1,667 to CZK 2,468. The cheapest bus tickets available in the next few weeks are for trips departing on November 5, 2026. If you’re looking to travel to Knoxville, TN this week, bus tickets are available starting at CZK 1,797.

Prices as travel date approaches

CZK 3,150CZK 2,520CZK 1,890CZK 1,260CZK 630020

Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 27 days in advance. This way, you can save up to CZK 1,506.30 on your bus ticket compared to booking last-minute.

What bus companies travel from Cleveland, OH to Knoxville, TN?

There is one intercity bus company available to search and book on Wanderu that operates from Cleveland, OH to Knoxville, TN. Greyhound is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.

BusDaily TripsAvg. TimeAvg. Price
Greyhound221h 44mCZK 2,224.61

  • Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 2 bus trips from Cleveland, OH to Knoxville, TN every day, with the average journey taking around 21 hours and 44 minutes to complete. Bus tickets for Greyhound trips to Knoxville, TN usually start from CZK 1,622.75.

    Passengers boarding a Greyhound with their cheap bus tickets, ready for a comfortable and budget-friendly trip - WanderuA Greyhound bus parked, waiting for passengers with cheap bus tickets ready to travel - WanderuComfortable seating inside a Greyhound, perfect for those traveling with cheap bus tickets who want to make the most of their journey - WanderuA passenger using the power outlets available on Greyhound to access their affordable bus ticket digitally - WanderuA passenger uses Greyhound's onboard wifi to enjoy their intercity bus trip - WanderuA bus awaits passengers who have bought cheap Greyhound tickets - Wanderu

Frequently asked questions about traveling by bus from Cleveland, OH to Knoxville, TN

There are usually only 2 buses per day from Cleveland, OH to Knoxville, TN. However, neither bus offers direct service, so you will have to get off your original vehicle to transfer buses during the trip.

Trips per day

2

Direct trips

0

The bus takes an average of 21 hours and 44 minutes to cover the 401 miles from Cleveland, OH to Knoxville, TN. However, the fastest bus only takes 15 hours and 25 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.

Distance (mi)

401

Distance (km)

645

The first bus leaves at 4:25 AM and the last bus leaves at 3:50 PM. To see the times for all buses from Cleveland, OH to Knoxville, TN, enter your specific travel dates in the search bar.

Earliest bus

4:25am

Latest bus

3:50pm

Thursday is usually the day of the week when buses are busiest. If you are planning to travel on a Thursday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Monday is typically the least busy day for bus travel on this route. For a less crowded trip, try to book your bus travel for the beginning of the week.

Most crowded

Thursday

Least crowded

Monday

City Information

Cleveland

CLE-0CLE-1CLE-2

An industrial powerhouse in the past eras, Cleveland offers to the world more than just LeBron James and Halle Berry. Unlike most other big cities, Cleveland still retains its quaint small-town feel, especially as you wander around the Cleveland Metroparks, a system of 21,000 acres of pure nature. For nature lovers, the Cleveland Botanical Garden provides a treasure trove of botanical knowledge and rare plant species. Another must-not-miss spot is the Rock & Roll Hall of Fame, which features exhibitions on the greatest legends such as Jimi Hendrix, The Beatles, etc.

For foodies, Cleveland truly is a mecca. The city boasts an array of top chefs and high-class establishments that can bring you an unforgettable experience. For authentic American classics, Sylman’s Deli has everything you need. If you are looking for a more diverse option, head to Momocho for some mouth-watering Mexican indulgences.

Cleveland’s main bus station is located just behind the Playhouse Square Parking Garage in the Theater District. The local Amtrak train station is also located downtown not too far from the bus station. The principal airport in the city is the Cleveland Hopkins International Airport, which sits 9 miles southwest of Downtown and is located next to the Glenn Research Center.

Station Information

Where does the bus leave from in Cleveland, OH?

Main departure station: E. 12th between Rockwell and St. Clair

Most buses depart from the main station in Cleveland, OH.

All bus stations in Cleveland, OH:

  • E. 12th between Rockwell and St. Clair

Where does the bus arrive in Knoxville, TN?

Main arrival station: Knoxville Bus Station

All buses from Cleveland, OH arrive at one main station in Knoxville, TN.

All bus stations in Knoxville, TN:

  • Knoxville Bus Station

Need a return trip from Knoxville, TN to Cleveland, OH?

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