Cheap bus tickets from Knoxville to Chicago
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Knoxville to Chicago Bus Schedule
Bus from Knoxville to Chicago: Journey Information
There are 7 intercity buses per day from Knoxville to Chicago. Traveling by bus from Knoxville to Chicago usually takes around 17 hours and 17 minutes, but the fastest Greyhound bus can make the trip in 14 hours and 40 minutes.
| Distance | 455 mi (732 km) |
| Shortest duration | 14h 40m |
| Cheapest price | DKK 388.08 |
| Most frequent service | Greyhound |
| Bus lines | 1 |
How much is a bus ticket from Knoxville to Chicago?
Bus tickets for a trip from Knoxville to Chicago cost DKK 754.81 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Chicago. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Knoxville to Chicago by travel date
Over the next four weeks, the average price of bus tickets from Knoxville to Chicago is expected to be between DKK 693 and DKK 1,042. The cheapest day to travel in the next month is November 11, 2025, when tickets are available for November 11, 2025. The cheapest bus tickets available in the next week start at just DKK 693.
Monthly avg. prices
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 18 days in advance. This way, you can save up to DKK 520.70 on your bus ticket compared to booking last-minute.
What bus companies travel from Knoxville to Chicago?
There is one intercity bus company available to search and book on Wanderu that operates from Knoxville to Chicago. Greyhound connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 7 | 17h 17m | DKK 817.01 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 7 bus trips from Knoxville to Chicago every day, with the average journey taking around 17 hours and 17 minutes to complete. Bus tickets for Greyhound trips to Chicago usually start from DKK 388.
Frequently asked questions about traveling by bus from Knoxville to Chicago
The bus takes an average of 17 hours and 17 minutes to cover the 455 miles from Knoxville to Chicago. However, the fastest bus only takes 14 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Thursday is usually the day of the week when buses are busiest. If you are planning to travel on a Thursday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
The first bus leaves at 6:00pm and the last bus leaves at 10:00pm. To see the times for all buses from Knoxville to Chicago, enter your specific travel dates in the search bar.
City Information
Chicago
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Knoxville?
Main departure station: Knoxville Bus Station
Most buses depart from the main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Where does the bus arrive in Chicago?
Image credit: Jeramey Jannene
Link to image attributionMain arrival station: Bus Station - 630 W Harrison St
Buses arrive in Chicago at 3 stations, depending on which bus line you are traveling with.
All bus stations in Chicago:
Bus Station - 630 W Harrison St
Dan Ryan Bus Station
Chicago Train Station Bus Stop
Get around town with Moovit
Need a return trip from Chicago to Knoxville?
Search Bus TicketsPlan your next adventure
More buses from Knoxville
- Chattanooga to Atlanta Bus
DKK 184+
- Bus from Chattanooga to Knoxville
DKK 181+
- Chattanooga to Nashville
DKK 174+
- Clarksville to Nashville
DKK 91+
- Jackson to Nashville Bus
DKK 217+
- Johnson City to New York
DKK 647+
- Knoxville to Atlanta Bus
DKK 278+
- Knoxville to Charlotte Bus
DKK 592+
- Bus from Knoxville to New York
DKK 647+
- Knoxville to Chattanooga Bus
DKK 175+
- Bus from Knoxville to Memphis
DKK 605+
- Knoxville to Nashville Bus
DKK 272+
- Bus from Memphis to Atlanta
DKK 505+
- Memphis to Nashville
DKK 352+
- Bus from Murfreesboro to Atlanta
DKK 254+
- Bus from Murfreesboro to Nashville
DKK 76+
- Bus from Nashville to Atlanta
DKK 276+
- Nashville to Memphis Bus
DKK 324+
Continue by bus from Chicago
- Bus from Chicago to Celaya
DKK 1,858+
- Chicago to Birmingham Bus
DKK 765+
- Bus from Chicago to Goshen
DKK 227+
- Chicago to Indianapolis
DKK 282+
- Bus from Chicago to New Orleans
DKK 1,009+
- Bus from Chicago to Detroit
DKK 303+
- Bus from Chicago to Flint
DKK 354+
- Bus from Chicago to Traverse City
DKK 346+
- Chicago to Minneapolis Bus
DKK 427+
- Bus from Chicago to St Louis
DKK 369+
- Bus from Chicago to Omaha
DKK 612+
- Bus from Chicago to Akron
DKK 422+
- Chicago to Oklahoma City Bus
DKK 1,234+
- Chicago to Richmond
DKK 1,118+
- Chicago to Milwaukee
DKK 182+
- Bus from Chicago to Wausau
DKK 215+
- Chicago to Charleston Bus
DKK 531+
Check out these popular routes
- Bus from Calgary to Edmonton
DKK 136+
- Bus from Vancouver to Seattle
DKK 239+
- Toronto to Ottawa Bus
DKK 139+
- Montreal to New York Bus
DKK 535+
- Bus from Atlanta to New York
DKK 811+
- Boston to New York
DKK 183+
- Brooklyn to Washington D.C. Bus
DKK 250+
- Ithaca to New York Bus
DKK 299+
- Bus from New York to Montreal
DKK 564+
- Bus from New York to Washington D.C.
DKK 180+
- Bus from New York to Boston
DKK 199+
- New York to Ithaca Bus
DKK 335+
- Bus from New York to Philadelphia
DKK 103+
- Philadelphia to Brooklyn Bus
DKK 97+
- Bus from Philadelphia to New York
DKK 105+
- Dallas to Houston Bus
DKK 260+
- Houston to Dallas Bus
DKK 239+
- Madison to Chicago Bus
DKK 237+
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.