|Fastest time||11h 25m|
|Trips per day||9|
Book Greyhound from Knoxville to Chicago from $42.27. There are 9 Greyhound schedules from Knoxville to Chicago and you can expect on average to pay $96.84 for a Greyhound ticket to Chicago. In Knoxville, Greyhound departs to Chicago from Bus Terminal - 100 E Magnolia Ave and no other station. In Chicago, Greyhound arrives at Union Station - 225 S Canal St and 3 other stations.
An average trip on Greyhound from Knoxville to Chicago takes 15 hours and 39 minutes, while the fastest available Greyhound trip will get you to Chicago in 11 hours and 25 minutes,
On weekends, Greyhound offers 10 trips per day and you could expect to pay $115.28 for a weekend getaway trip to Chicago.