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Greyhound Bus Lines is a popular bus company offering very affordable ticket options to top travel destinations. You will always find the cheapest Greyhound Bus Lines tickets by searching Wanderu.com. Overall, Greyhound Bus Lines serves 20,557 bus routes, connecting 142 cities in 2 countries. To cover all these routes Greyhound Bus Lines runs an average of 50,091 trips per day and 1,523,576 trips per month. These bus trips range in price from $5.18 to $11,501.07 based on a variety of factors.