|Shortest Duration||11h 15m|
|Trips per day||8|
Book Greyhound from Knoxville to Chicago from $35.00. There are 8 trips per day offered by Greyhound from Knoxville to Chicago and you can expect on average to pay $86.71 for a Greyhound ticket to Chicago. In Knoxville, Greyhound departs to Chicago from Bus Terminal - 100 E Magnolia Ave, In Chicago, Greyhound arrives at Bus Station - 630 W Harrison St and 3 other stations.
An average trip on Greyhound from Knoxville to Chicago takes 14 hours and 56 minutes, while the fastest available Greyhound trip will get you to Chicago in 11 hours and 15 minutes,
On weekends, Greyhound offers 8 trips per day. A one way ticket costs $92.38 for a weekend trip to Chicago.