Cheap bus tickets from Greenville, SC to Chicago, IL
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Bus from Greenville, SC to Chicago, IL: Journey Information
There are 6 intercity buses per day from Greenville, SC to Chicago, IL. Traveling by bus from Greenville, SC to Chicago, IL usually takes around 25 hours and 21 minutes, but the fastest FlixBus US bus can make the trip in 19 hours and 40 minutes.
| Distance | 562 mi (904 km) |
| Shortest duration | 19h 40m |
| Cheapest price | $89.46 |
| Trips per day | 0 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |
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Greenville to Chicago Bus Schedule
There are several bus options that can take you from Greenville to Chicago:
See more detailsHow much is a bus ticket from Greenville, SC to Chicago, IL?
Bus tickets for a trip from Greenville, SC to Chicago, IL cost $97.47 on average. While it’s a bit pricey for a bus ticket, it’s still significantly more cost-effective than flying. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Greenville, SC to Chicago, IL by travel date
If you're planning to travel by bus from Greenville, SC to Chicago, IL in the next month, the average ticket price is expected to range from $95 to $164. The cheapest bus tickets available in the next few weeks are for trips departing on September 14, 2026. If you’re looking to travel to Chicago, IL this week, bus tickets are available starting at $103.
Average bus ticket prices from Greenville, SC to Chicago, IL by month
Taking the bus from Greenville, SC to Chicago, IL is usually cheapest in September, when the average ticket price is only $162. If you're planning to take the bus from Greenville, SC to Chicago, IL during December, keep in mind that bus ticket prices may be higher than usual, with an average price of $222. However, booking your trip in advance can help you score a ticket at a better price.
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 28 days in advance. This way, you can save up to $154.12 on your bus ticket compared to booking last-minute.
What bus companies travel from Greenville to Chicago?
There are multiple buses that travel from Greenville to Chicago, including FlixBus US. Here is what you should know about the 1 most popular bus lines:
| BUS | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 6 | 25h 21m | $214.31 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 6 trips per day from Greenville, SC to Chicago, IL, and the average ticket for this route costs only $214.31.
Frequently asked questions about traveling by bus from Greenville to Chicago
There are 6 scheduled buses that travel from Greenville, SC to Chicago, IL every day, so you have a decent number of options to choose from. Unfortunately, none of them are direct connections, so no matter which bus you take, you will have to transfer buses at least once during your journey. Need more travel options? Consider taking the train from Greenville, SC to Chicago, IL; ticket prices start at $180.
TRIPS PER DAY
6
DIRECT TRIPS
0
The bus takes an average of 25 hours and 21 minutes to cover the 562 miles from Greenville, SC to Chicago, IL. However, the fastest bus only takes 19 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
DISTANCE (MI)
562
DISTANCE (KM)
904
The first bus leaves at 1:20pm and the last bus leaves at 9:35pm. To see the times for all buses from Greenville, SC to Chicago, IL, enter your specific travel dates in the search bar.
EARLIEST BUS
1:20pm
LATEST BUS
9:35pm
Because many passengers travel from Greenville, SC to Chicago, IL at the beginning of the work week, Monday is usually the busiest day for buses. If you are planning to travel on a Monday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.
MOST CROWDED
Monday
LEAST CROWDED
Thursday
City Information
Greenville, SC
As the sixth-largest city in the state of South Carolina, Greenville is one of the state's hidden treasures! The city is a vibrant hub of artistic activities and exhibitions, with many on display at the Greenville County Museum of Art. For fans of automobiles, especially BMW cars, the BMW Zentrum will offer a comprehensive look at the brand's past, present, and future. To get close to nature, check out Cedar Falls Park, which features a majestic 200-foot wide waterfall as well as plenty of other scenic spots.
The city of Greenville boasts a vibrant food scene with plenty of signature Southern dishes. One of the best places in town to enjoy an authentic Southern BBQ dinner is at Bacon Bros. Public House, which offers impressive dishes at very affordable prices. For a more upscale dining experience, check out Passerelle Bistro, where you can have some of the finest French dishes.
Greenville is well-connected by both buses and trains, with frequent service to destinations like Orlando, New Orleans, Richmond, and even New York. Plus, the Greenville-Spartanburg International Airport is only 15 minutes from downtown Greenville.
Chicago, IL
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Greenville?
Main departure station: 1116 Woodruff Rd
Most buses depart from the main station in Greenville, SC.
All bus stations in Greenville:
- 1116 Woodruff Rd
Where does the bus arrive in Chicago?
Main arrival station: Chicago Train Station Bus Stop
Buses arrive in Chicago, IL at 3 stations, depending on which bus line you are traveling with.
All bus stations in Chicago:
- Chicago Train Station Bus Stop
- Bus Station - 630 W Harrison St
- Dan Ryan Bus Station
Need a return trip from Chicago to Greenville?
Search Bus TicketsPlan your next adventure
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