Cheap bus tickets from Knoxville to Chicago
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Knoxville to Chicago Bus Schedule
Bus from Knoxville to Chicago: Journey Information
There are 7 intercity buses per day from Knoxville to Chicago. Traveling by bus from Knoxville to Chicago usually takes around 17 hours and 17 minutes, but the fastest Greyhound bus can make the trip in 14 hours and 40 minutes.
| Distance | 455 mi (732 km) |
| Shortest duration | 14h 40m |
| Cheapest price | RON 264.35 |
| Most frequent service | Greyhound |
| Bus lines | 1 |
How much is a bus ticket from Knoxville to Chicago?
Bus tickets for a trip from Knoxville to Chicago cost RON 514.14 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Chicago. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Knoxville to Chicago by travel date
Over the next four weeks, the average price of bus tickets from Knoxville to Chicago is expected to be between RON 472 and RON 710. The cheapest day to travel in the next month is November 11, 2025, when tickets are available for November 11, 2025. The cheapest bus tickets available in the next week start at just RON 472.
Monthly avg. prices
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To find the cheapest bus tickets, book your trip at least 18 days in advance. This way, you can save up to RON 354.68 on your bus ticket compared to booking last-minute.
What bus companies travel from Knoxville to Chicago?
There is one intercity bus company available to search and book on Wanderu that operates from Knoxville to Chicago. Greyhound connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 7 | 17h 17m | RON 556.51 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 7 bus trips from Knoxville to Chicago every day, with the average journey taking around 17 hours and 17 minutes to complete. Bus tickets for Greyhound trips to Chicago usually start from RON 264.
Frequently asked questions about traveling by bus from Knoxville to Chicago
The bus takes an average of 17 hours and 17 minutes to cover the 455 miles from Knoxville to Chicago. However, the fastest bus only takes 14 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Thursday is usually the day of the week when buses are busiest. If you are planning to travel on a Thursday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
The first bus leaves at 6:00pm and the last bus leaves at 10:00pm. To see the times for all buses from Knoxville to Chicago, enter your specific travel dates in the search bar.
City Information
Chicago
Known for its innovative architecture, cultural contributions to jazz and house music, and of course that irresistible deep-dish pizza, the many sights and experiences in Chicago make it one of the best urban vacation destinations for millennials and a top destination in Illinois.
You can't beat the views of the city and Lake Michigan from the SkyDeck in the Willis Tower; at over 1,300 feet, this is the highest observation deck in the U.S. Snap that classic selfie with the Bean in Millennium Park, then wander the many museums in nearby Grant Park. Navy Pier is a popular tourist hotspot for its parks, restaurants, and attractions right on Lake Michigan, and baseball fans will find paradise in Wrigleyville, home to the Chicago Cubs' Wrigley Field and sports bars galore.
Chicago's enormous parks offer plentiful opportunities for outdoor activities in gorgeous urban settings. Many companies offer kayak rentals or boat tours on the Chicago River, with special tours running on Saint Patrick's Day, when the entire river is dyed green. When you’re ready to buy some souvenirs from your epic trip, hit the big brand stores on the Magnificent Mile, or shop local in neighborhoods like Andersonville and Wicker Park. And don't miss the chance to laugh until you cry at The Second City comedy theater, famous for launching the careers of comedians like Tina Fey and Stephen Colbert.
Chicago is one of the biggest transportation hubs in the Midwest, and provides easy access to nearby destinations ideal for day trips, as well as international travel from two airports. Thanks to plenty of bus and train stations throughout the city, getting to the Windy City is a breeze.
Station Information
Where does the bus leave from in Knoxville?
Main departure station: Knoxville Bus Station
Most buses depart from the main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Where does the bus arrive in Chicago?
Image credit: Jeramey Jannene
Link to image attributionMain arrival station: Bus Station - 630 W Harrison St
Buses arrive in Chicago at 3 stations, depending on which bus line you are traveling with.
All bus stations in Chicago:
Bus Station - 630 W Harrison St
Dan Ryan Bus Station
Chicago Train Station Bus Stop
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