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Isilines is a popular bus company offering very affordable ticket options to top travel destinations. You will always find the cheapest Isilines tickets by searching Wanderu.com. Overall, Isilines serves 712 bus routes, connecting 59 cities in 2 countries. To cover all these routes Isilines runs an average of 479 trips per day and 14,557 trips per month. These bus trips range in price from $3.73 to $133.40 based on a variety of factors.