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Isilines is a popular bus company offering very affordable ticket options to top travel destinations. You will always find the cheapest Isilines tickets by searching Wanderu.com. Overall, Isilines serves 773 bus routes, connecting 61 cities in 2 countries. To cover all these routes Isilines runs an average of 315 trips per day and 9,560 trips per month. These bus trips range in price from $5.31 to $229.99 based on a variety of factors.