Cheap bus tickets from Mesa to Irvine
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Mesa to Irvine Bus Schedule
Bus from Mesa to Irvine: Journey Information
There are 2 intercity buses per day from Mesa to Irvine. Traveling by bus from Mesa to Irvine usually takes around 20 hours and 52 minutes, but the fastest Greyhound bus can make the trip in 18 hours and 30 minutes.
| Distance | 344 mi (553 km) |
| Shortest duration | 18h 30m |
| Cheapest price | $47.79 |
| Most frequent service | Greyhound |
| Bus lines | 1 |

What bus companies travel from Mesa to Irvine?
There is one intercity bus company available to search and book on Wanderu that operates from Mesa to Irvine. Greyhound is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Greyhound | 2 | 20h 52m | $103.70 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 2 bus trips from Mesa to Irvine every day, with the average journey taking around 20 hours and 52 minutes to complete. Bus tickets for Greyhound trips to Irvine usually start from $48.
Frequently asked questions about traveling by bus from Mesa to Irvine
The bus takes an average of 20 hours and 52 minutes to cover the 344 miles from Mesa to Irvine. However, the fastest bus only takes 18 hours and 30 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Friday is the busiest travel day for buses as people head from Mesa to Irvine for the weekend. If you are planning to travel on a Friday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.
The first bus leaves at 2:00pm and the last bus leaves at 9:00pm. To see the times for all buses from Mesa to Irvine, enter your specific travel dates in the search bar.
City Information
Irvine

Image credit: Unsplash

Image credit: Unsplash

Image credit: Unsplash
Though Irvine is probably most famous for its corporations and university campuses, the city is well worth the trip for its variety of attractions and activities. Start with a date night at the Irvine Barclay Theatre, which boasts an intimate atmosphere and superb acoustics. You could also check out the UCI Arboretum, where you can learn more about the unique flora of the coastal California region. The Beall Center for Art + Technology features interesting exhibitions that fuse modern art with futuristic technologies.
When you've worked up an appetite, you can find a wide variety of dining options available in the city. For some of the best Japanese dishes in town, check out Fukuda, which serves udon and soba dishes. If you are craving a good chicken parm, North Italia has just what you need!
It's easy to get to Irvine from anywhere in Southern California via intercity buses or Amtrak trains. Flights operate through the nearby John Wayne Airport-Orange County Airport, just 4.3 miles away from downtown.
Station Information
Where does the bus leave from in Mesa?
Main departure station: Bus Station
Most buses depart from the main station in Mesa.
All bus stations in Mesa:
Bus Station
Where does the bus arrive in Irvine?
Main arrival station: University of CA - Crawford Hall
All buses from Mesa arrive at one main station in Irvine.
All bus stations in Irvine:
University of CA - Crawford Hall
Get around town with Moovit
Need a return trip from Irvine to Mesa?
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- Mesa to Irvine






