FlixBus operates, on average, 2 bus schedule(s) from Mainz to Rome. The average FlixBus ticket to Rome costs $67.59. Cheap FlixBus tickets to Rome are available on Wanderu starting from $63.90. In Mainz, FlixBus departs from Central Station and no other station. In Rome, FlixBus arrives at Largo Guido Mazzoni and no other station.
An average trip on FlixBus from Mainz to Rome takes 23 hours and 0 minutes, while the fastest available FlixBus trip will get you to Rome in 22 hours and 0 minutes,