Cheap bus tickets from Mexico City to Panama City
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Mexico City to Panama City Bus Schedule
Bus from Mexico City to Panama City: Journey Information
There are 4 intercity buses per day from Mexico City to Panama City. Traveling by bus from Mexico City to Panama City usually takes around 49 hours and 56 minutes, but the fastest FlixBus US bus can make the trip in 43 hours and 5 minutes.
| Distance | 1122 mi (1806 km) |
| Shortest duration | 43h 5m |
| Cheapest price | $195.96 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Mexico City to Panama City?
There is one intercity bus company available to search and book on Wanderu that operates from Mexico City to Panama City. FlixBus US connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 4 | 2d 1h 56m | $230.39 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 4 trips per day from Mexico City to Panama City, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Mexico City to Panama City
The bus takes an average of 49 hours and 56 minutes to cover the 1122 miles from Mexico City to Panama City. However, the fastest bus only takes 43 hours and 5 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Friday is the busiest travel day for buses as people head from Mexico City to Panama City for the weekend. If you are planning to travel on a Friday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Sunday is typically the least busy day for bus travel on this route. If you are looking for less crowded buses to Panama City, book your ticket for the last day of the week.
The first bus leaves at 9:00am and the last bus leaves at 11:00pm. To see the times for all buses from Mexico City to Panama City, enter your specific travel dates in the search bar.
City Information
Mexico City



Mexico City is one of the most vibrant and liveliest cities in the world, making it an exciting destination for all travelers. One of the must-see attractions in the city is the famous Museo Nacional de Antropología, which features an extensive collection from the city’s pre-Columbian era. Its star attraction is the famous Aztec Calendar Stone, also known as Piedra del Sol. For those who enjoy exploring the city’s amazing cultural life, the Palacio de Bellas Artes is a must-see destination. The art deco-style palace hosts some of the grandest cultural events around, including concerts, operas, etc. Another unique destination to check out is Teotihuacán, a world heritage site that contains some of the largest pre-Columbian pyramids in Mexico.
Mexico City’s food scene is so vast that it can be quite hard to fully explore in just a few days. Some notable foodie destinations include Pujol, Contramar, and Quintonil. If you want to grab one of those famous Mexican churros, head over to Churreria El Moro.
Mexico City’s four major bus stations are North, South, Observatorio, and TAPO. Some intercity buses leave directly from the Mexico City International Airport, which is located just about 7 miles east of the city center.
Station Information
Where does the bus leave from in Mexico City?
Main departure station: Mexico City Buenavista (Forum)
Mexico City has two bus stations with service to Panama City.
All bus stations in Mexico City:
Mexico City Buenavista (Forum)
Buenavista - San Pedro Santa Clara
Where does the bus arrive in Panama City?
Main arrival station: Panama City Bch Station
All buses from Mexico City arrive at one main station in Panama City.
All bus stations in Panama City:
Panama City Bch Station
Get around town with Moovit
Need a return trip from Panama City to Mexico City?
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