Cheap bus tickets from Panama City to Mexico City
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Bus from Panama City to Mexico City: Journey Information
There are 2 intercity buses per day from Panama City to Mexico City. Traveling by bus from Panama City to Mexico City usually takes around 67 hours and 33 minutes, but the fastest Greyhound bus can make the trip in 66 hours and 40 minutes.
Distance | 1122 mi (1806 km) |
Shortest duration | 66h 40m |
Cheapest price | $164.00 |
Most frequent service | Greyhound |
Bus lines | 1 |

What bus companies travel from Panama City to Mexico City?
There is one intercity bus company available to search and book on Wanderu that operates from Panama City to Mexico City. Greyhound is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.
Bus | Daily Trips | Avg. Time | Avg. Price |
---|---|---|---|
Greyhound | 2 | 2d 19h 33m | $167.00 |
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 2 bus trips from Panama City to Mexico City every day, with the average journey taking around 67 hours and 33 minutes to complete. Bus tickets for Greyhound trips to Mexico City usually start from $164.
Frequently asked questions about traveling by bus from Panama City to Mexico City
The bus takes an average of 67 hours and 33 minutes to cover the 1122 miles from Panama City to Mexico City. However, the fastest bus only takes 66 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
The first bus leaves at 8:00am and the last bus leaves at 7:00pm. To see the times for all buses from Panama City to Mexico City, enter your specific travel dates in the search bar.
City Information
Mexico City



Mexico City is one of the most vibrant and liveliest cities in the world, making it an exciting destination for all travelers. One of the must-see attractions in the city is the famous Museo Nacional de Antropología, which features an extensive collection from the city’s pre-Columbian era. Its star attraction is the famous Aztec Calendar Stone, also known as Piedra del Sol. For those who enjoy exploring the city’s amazing cultural life, the Palacio de Bellas Artes is a must-see destination. The art deco-style palace hosts some of the grandest cultural events around, including concerts, operas, etc. Another unique destination to check out is Teotihuacán, a world heritage site that contains some of the largest pre-Columbian pyramids in Mexico.
Mexico City’s food scene is so vast that it can be quite hard to fully explore in just a few days. Some notable foodie destinations include Pujol, Contramar, and Quintonil. If you want to grab one of those famous Mexican churros, head over to Churreria El Moro.
Mexico City’s four major bus stations are North, South, Observatorio, and TAPO. Some intercity buses leave directly from the Mexico City International Airport, which is located just about 7 miles east of the city center.
Station Information
Where does the bus leave from in Panama City?
Main departure station: 917 Harrison Ave
Most buses depart from the main station in Panama City.
All bus stations in Panama City:
917 Harrison Ave
Where does the bus arrive in Mexico City?

Image credit: Juan Carlos Fonseca Mata
Link to image attributionMain arrival station: Eje Ctrl Lazaro Cardenas
All buses from Panama City arrive at one main station in Mexico City.
All bus stations in Mexico City:
Eje Ctrl Lazaro Cardenas
Get around town with Moovit
Need a return trip from Mexico City to Panama City?
Search Bus TicketsPlan your next adventure
More buses from Panama City
Continue by bus from Mexico City
Check out these popular routes

Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.
- Bus Tickets
- Mexico
- Ciudad de México
- Mexico City
- Panama City to Mexico City