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Cheap bus tickets from Panama City to Mexico City

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Panama City to Mexico City Bus Schedule

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Bus from Panama City to Mexico City: Journey Information

There are 2 intercity buses per day from Panama City to Mexico City. Traveling by bus from Panama City to Mexico City usually takes around 67 hours and 33 minutes, but the fastest Greyhound bus can make the trip in 66 hours and 40 minutes.

Distance1122 mi (1806 km)
Shortest duration66h 40m
Cheapest price$164.00
Most frequent serviceGreyhound
Bus lines1

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What bus companies travel from Panama City to Mexico City?

There is one intercity bus company available to search and book on Wanderu that operates from Panama City to Mexico City. Greyhound is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.

BusDaily TripsAvg. TimeAvg. Price
Greyhound22d 19h 33m$167.00
  • Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 2 bus trips from Panama City to Mexico City every day, with the average journey taking around 67 hours and 33 minutes to complete. Bus tickets for Greyhound trips to Mexico City usually start from $164.

Frequently asked questions about traveling by bus from Panama City to Mexico City

The bus takes an average of 67 hours and 33 minutes to cover the 1122 miles from Panama City to Mexico City. However, the fastest bus only takes 66 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.

The busiest and least busy days to travel on this route tend to change frequently from week to week. Weather, holidays, local events, and other factors can affect how crowded the bus is on any given day.

The first bus leaves at 8:00am and the last bus leaves at 7:00pm. To see the times for all buses from Panama City to Mexico City, enter your specific travel dates in the search bar.

There are usually only 2 buses per day from Panama City to Mexico City. However, neither bus offers direct service, so you will have to get off your original vehicle to transfer buses during the trip.

City Information

Mexico City

Mexico City is one of the most vibrant and liveliest cities in the world, making it an exciting destination for all travelers. One of the must-see attractions in the city is the famous Museo Nacional de Antropología, which features an extensive collection from the city’s pre-Columbian era. Its star attraction is the famous Aztec Calendar Stone, also known as Piedra del Sol. For those who enjoy exploring the city’s amazing cultural life, the Palacio de Bellas Artes is a must-see destination. The art deco-style palace hosts some of the grandest cultural events around, including concerts, operas, etc. Another unique destination to check out is Teotihuacán, a world heritage site that contains some of the largest pre-Columbian pyramids in Mexico.

Mexico City’s food scene is so vast that it can be quite hard to fully explore in just a few days. Some notable foodie destinations include Pujol, Contramar, and Quintonil. If you want to grab one of those famous Mexican churros, head over to Churreria El Moro.

Mexico City’s four major bus stations are North, South, Observatorio, and TAPO. Some intercity buses leave directly from the Mexico City International Airport, which is located just about 7 miles east of the city center.

Station Information

Where does the bus leave from in Panama City?

Main departure station: 917 Harrison Ave

Most buses depart from the main station in Panama City.

All bus stations in Panama City:

  • 917 Harrison Ave

Where does the bus arrive in Mexico City?

Eje Ctrl Lazaro Cardenas  - MXMEXGLI-0

Image credit: Juan Carlos Fonseca Mata

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Main arrival station: Eje Ctrl Lazaro Cardenas

All buses from Panama City arrive at one main station in Mexico City.

All bus stations in Mexico City:

  • Eje Ctrl Lazaro Cardenas

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