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Knoxville to Harrisburg bus

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Knoxville - Harrisburg Bus Schedule

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Journey Information

There are 4 intercity buses per day from Knoxville to Harrisburg. Traveling by bus from Knoxville to Harrisburg usually takes around 21 hours and 20 minutes, but the fastest Greyhound bus can make the trip in 16 hours and 40 minutes.

Distance484 mi (780 km)
Shortest duration16h 40m
Cheapest price$134.82
Most frequent serviceGreyhound
Bus lines1

What bus companies travel from Knoxville to Harrisburg?

There is one intercity bus company available to search and book on Wanderu that operates from Knoxville to Harrisburg. Greyhound connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.

BusDaily TripsAvg. TimeAvg. Price
Greyhound421h 21m$157.00
  • Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 4 bus trips from Knoxville to Harrisburg every day, with the average journey taking around 21 hours and 21 minutes to complete. Bus tickets for Greyhound trips to Harrisburg usually start from $135.

Frequently Asked Questions

The bus takes an average of 21 hours and 20 minutes to cover the 484 miles from Knoxville to Harrisburg. However, the fastest bus only takes 16 hours and 40 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.

Friday is the busiest travel day for buses as people head from Knoxville to Harrisburg for the weekend. If you are planning to travel on a Friday, you should make sure to book tickets well in advance as they may sell out.

On the other hand, Thursday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Thursday ticket is the way to go.

The first bus leaves at 12:00am and the last bus leaves at 10:00pm. To see the times for all buses from Knoxville to Harrisburg, enter your specific travel dates in the search bar.

There are 4 scheduled buses that travel from Knoxville to Harrisburg every day, so you have a decent number of options to choose from. Unfortunately, none of them are direct connections, so no matter which bus you take, you will have to transfer buses at least once during your journey.

City Information

Harrisburg

As the capital city of Pennsylvania, Harrisburg offers numerous historic buildings with impressive architecture that will leave you in awe. Among the most impressive ones is the state’s Capitol Complex itself. With a dome that reminisces St. Peter’s Basilica in Rome, the building features as many as 475 rooms filled with exquisite artworks and statues. History fans should also consider visiting the State Museum of Pennsylvania, which follows the history of the state from the beginning of time to this day. Another must-see destination is the National Civil War Museum, which is one of the largest museums dedicated to the Civil War. If too many history lessons stress you out, a cruise along the Susquehanna River on the Pride of the Susquehanna Riverboat will definitely help you unwind.

Harrisburg’s grilled dishes are some of the most famous staples in the city, and among the best establishments is Progress Grill, which has been serving customers since the late 1940s. For some really creative pizzas, The Pizza Grille will be a good choice.

The Harrisburg Transportation Center is the central hub for intercity travel. At the lower level, you can catch a bus by Greyhound, Jefferson Lines or Fullington Trailways to other Pennsylvanian cities such as Allentown and Philadelphia. Travelers can also take Amtrak trains to popular destinations like New York and Philadelphia on a daily basis. The city’s principal airport is Harrisburg International Airport, which is located in Middletown, southeast of the city.

Station Information

Where does the bus leave from in Knoxville?

Main departure station: Knoxville Bus Station

Most buses depart from the main station in Knoxville.

All bus stations in Knoxville:

  • Knoxville Bus Station

Where does the bus arrive in Harrisburg?

Main arrival station: Harrisburg Transportation Center

All buses from Knoxville arrive at one main station in Harrisburg.

All bus stations in Harrisburg:

  • Harrisburg Transportation Center

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