Cheap bus tickets from Santa Ana to Lexington
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Santa Ana to Lexington Bus Schedule
Bus from Santa Ana to Lexington: Journey Information
There is one daily bus from Santa Ana to Lexington. Traveling by bus from Santa Ana to Lexington usually takes around 54 hours and 50 minutes, but some buses might arrive slightly earlier or later than scheduled depending on traffic conditions.
| Distance | 1881 mi (3027 km) |
| Shortest duration | 54h 50m |
| Cheapest price | $255.44 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Santa Ana to Lexington?
There is one intercity bus company available to search and book on Wanderu that operates from Santa Ana to Lexington. FlixBus US is the only company that has bus schedules available to search and book at the moment. It only makes the trip once a day on most days.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 1 | 2d 6h 50m | $255.44 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 1 trips per day from Santa Ana to Lexington, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Santa Ana to Lexington
The bus takes an average of 54 hours and 50 minutes to cover the 1881 miles from Santa Ana to Lexington. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
There is usually only one bus per day from Santa Ana to Lexington. It leaves the station in Santa Ana at 1:00pm each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.
City Information
Santa Ana

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Santa Ana is a sunny city in Orange County located between Anaheim and Irvine in the greater Los Angeles area. Downtown Santa Ana bustles with independent breweries, diverse restaurants, unique retail shops, weekly pop-up markets, and art centers. This lively downtown area, in addition to Santa Ana's live-work housing and creative working spaces, make it attractive to young professionals.
One of the most popular spots for visitors is the Santa Ana Zoo, where little ones can enjoy a carousel and mini-train ride along with the animal exhibits. Architecture enthusiasts will love seeing the Bowers Museum, built in a Mission Revival style, and the Heritage Museum, which has restored homes from the 1890s.
The Orange County Transportation Authority and several shuttle services provide transit within Santa Ana. Santa Ana is easily accessible from over 20 other cities by Amtrak Thruway bus or on the Amtrak Pacific Surfliner train. The primary airport for Orange County, John Wayne Airport, is located in Santa Ana and also makes it easy to travel to this vibrant SoCal spot.
Lexington

Image credit: Unsplash

Image credit: Unsplash

Image credit: Pixabay
Located at the heart of Bluegrass Country, Lexington is sometimes called the horse capital of the world for its thoroughbred stud farms. The second-largest city in Kentucky, Lexington was named after the battle of the American Revolutionary War, and it was founded just a year before the Declaration of Independence was signed.
The presence of some of the nation's brightest minds at the University of Kentucky has helped foster a cultured air and led Lexington to take another nickname, the Athens of the West.
Downtown Lexington remains the place to see and be seen, hosting many of the city's top hotels and a handful of grassroots distilleries. You’ll be happy to know that Lexington is the city with the second cheapest pint of beer on average, so plan to hit up some breweries. Slightly east lies the Gratz Park district, home to several important buildings, including Hunt-Morgan House. A relatively modest red brick structure by today's Lexington standards, it was built by the first millionaire west of the Allegheny Mountains.
Travel to and from Lexington couldn't be simpler, thanks to no less than 180 different bus routes. There's certainly little difficulty reaching the state capital Frankfort, the rock 'n' roll sounds of Memphis, or the laid-back vibes of New Orleans.
Station Information
Where does the bus leave from in Santa Ana?
Main departure station: Reg Transp Ctr - 1000 E Santa Ana Blvd
Most buses depart from the main station in Santa Ana.
All bus stations in Santa Ana:
Reg Transp Ctr - 1000 E Santa Ana Blvd
Where does the bus arrive in Lexington?
Main arrival station: 477 W New Circle Rd NW
The Greyhound bus station in Lexington is located on W New Circle Road, near the Green Acres, Elkhorn Park, and Radcliffe neighborhoods. It is about three miles from the center of the city. The bus station has restrooms and vending machines inside, but the station has limited hours; be prepared to wait for your bus outside or in one of the surrounding fast-food restaurants. Luckily, the station is in a strip mall that is also home to a bakery, pizza joint, Burger King, and a Family Dollar.
All bus stations in Lexington:
477 W New Circle Rd NW
Get around town with Moovit
Need a return trip from Lexington to Santa Ana?
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- Bus Tickets
- United States
- Kentucky
- Lexington
- Santa Ana, CA to Lexington, KY





