Cheap bus tickets from Santa Ana to Grand Junction
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Santa Ana to Grand Junction Bus Schedule
Bus from Santa Ana to Grand Junction: Journey Information
There is one daily bus from Santa Ana to Grand Junction. Traveling by bus from Santa Ana to Grand Junction usually takes around 19 hours and 50 minutes, but some buses might arrive slightly earlier or later than scheduled depending on traffic conditions.
| Distance | 635 mi (1021 km) |
| Shortest duration | 19h 50m |
| Cheapest price | $125.97 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Santa Ana to Grand Junction?
There is one intercity bus company available to search and book on Wanderu that operates from Santa Ana to Grand Junction. FlixBus US is the only company that has bus schedules available to search and book at the moment. It only makes the trip once a day on most days.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 1 | 19h 50m | $125.97 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 1 trips per day from Santa Ana to Grand Junction, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Santa Ana to Grand Junction
The bus takes an average of 19 hours and 50 minutes to cover the 635 miles from Santa Ana to Grand Junction. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
There is usually only one bus per day from Santa Ana to Grand Junction. It leaves the station in Santa Ana at 4:00pm each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.
There is usually only one bus per day from Santa Ana to Grand Junction. However, it is not a direct bus, so you will have to get off your original vehicle to change buses during the trip.
Need more travel options? Consider taking the train from Santa Ana to Grand Junction; ticket prices start at $230.00.
City Information
Santa Ana

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Santa Ana is a sunny city in Orange County located between Anaheim and Irvine in the greater Los Angeles area. Downtown Santa Ana bustles with independent breweries, diverse restaurants, unique retail shops, weekly pop-up markets, and art centers. This lively downtown area, in addition to Santa Ana's live-work housing and creative working spaces, make it attractive to young professionals.
One of the most popular spots for visitors is the Santa Ana Zoo, where little ones can enjoy a carousel and mini-train ride along with the animal exhibits. Architecture enthusiasts will love seeing the Bowers Museum, built in a Mission Revival style, and the Heritage Museum, which has restored homes from the 1890s.
The Orange County Transportation Authority and several shuttle services provide transit within Santa Ana. Santa Ana is easily accessible from over 20 other cities by Amtrak Thruway bus or on the Amtrak Pacific Surfliner train. The primary airport for Orange County, John Wayne Airport, is located in Santa Ana and also makes it easy to travel to this vibrant SoCal spot.
Grand Junction

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Grand Junction is a popular wine destination about four hours west of Denver and close to Colorado's border with Utah. The area is home to over 30 wineries with award-winning red wines and breathtaking views. While any vineyard or winery is worth the tour, consider booking a room to stay a while in the Chateau at Two Rivers Winery.
The Colorado River and the red rock formations around Grand Junction make the area ideal for exploring the outdoors. Take in the incredible plateau and canyon vistas at the Colorado National Monument in Grand Junction, easily one of the best destinations in Colorado. Spot wild horses on the trail to the Mount Garfield summit, or spend a serene day fishing at James M. Robb State Park.
Grand Junction Airport has direct flights to a handful of western cities, but taking the train is more convenient for connections to further destinations. The Amtrak California Zephyr stops in Grand Junction on its route from Chicago to Emeryville, with additional stops in Denver and Salt Lake City. Jefferson Lines buses also stop in the city, heading to destinations across the midwest.
Station Information
Where does the bus leave from in Santa Ana?
Main departure station: Reg Transp Ctr - 1000 E Santa Ana Blvd
Most buses depart from the main station in Santa Ana.
All bus stations in Santa Ana:
Reg Transp Ctr - 1000 E Santa Ana Blvd
Where does the bus arrive in Grand Junction?
Main arrival station: Shell
All buses from Santa Ana arrive at one main station in Grand Junction.
All bus stations in Grand Junction:
Shell
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Need a return trip from Grand Junction to Santa Ana?
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- Colorado
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- Santa Ana to Grand Junction






