Cheap bus tickets from Des Moines to Guadalajara
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Des Moines to Guadalajara Bus Schedule
Bus from Des Moines to Guadalajara: Journey Information
There is one daily bus from Des Moines to Guadalajara. Traveling by bus from Des Moines to Guadalajara usually takes around 42 hours and 10 minutes, but some buses might arrive slightly earlier or later than scheduled depending on traffic conditions.
| Distance | 1555 mi (2502 km) |
| Shortest duration | 42h 10m |
| Cheapest price | $275.00 |
| Most frequent service | El Expreso Bus |
| Bus lines | 1 |

What bus companies travel from Des Moines to Guadalajara?
There is one intercity bus company available to search and book on Wanderu that operates from Des Moines to Guadalajara. El Expreso Bus is the only company that has bus schedules available to search and book at the moment. It only makes the trip once a day on most days.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| El Expreso Bus | 1 | 1d 18h 11m | $275.00 |
Frequently asked questions about traveling by bus from Des Moines to Guadalajara
The bus takes an average of 42 hours and 10 minutes to cover the 1555 miles from Des Moines to Guadalajara. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
There is usually only one bus per day from Des Moines to Guadalajara. It leaves the station in Des Moines at 3:00pm each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.
City Information
Des Moines

Image credit: Unsplash
Des Moines is the capital city of Iowa and the most populous city in the state. It has been named the third-largest insurance capital in the world because of its relevance in the US insurance industry. Des Moines is home to historic landmarks, especially in the East Village area. These include the gold-domed Iowa State Capitol building. Art lovers can visit the Des Moines Art Center, which has notable contemporary collections, and the Pappajohn Sculpture Park, a pedestrian space with public attractions. Des Moines also has spots for outdoor adventures, like the Blank Park Zoo, Greater Des Moines Botanical Garden, and Living History Farms.
Des Moines offers diverse places for entertainment, like the Praire Meadows Casino, Racetrack & Hotel, and the Salisbury House & Gardens, a concert venue in a 1920s manor. In the heart of the city is Downtown Des Moines, which has different attractions and entertainment venues, festivals and concerts, shopping spots, sports teams, restaurants, bars, and breweries.
It's very easy to access Des Moines when you're traveling by bus. Over a hundred neighboring cities offer bus lines to the city, powered by companies like Jefferson Lines, Tornado Bus, Burlington Trailways, and El Expreso Bus. The Des Moines Area Regional Transit Authority also provides bus routes throughout the city.
Guadalajara



Authentically Mexican and bustling with cultural activities, Guadalajara offers a more culturally vivid travel experience compared to the busy Mexico City. Guadalajara is blessed with towering architectural marvels, the most notable of which is the Guadalajara Cathedral that features awe-inspiring Gothic architecture and enormous stained-glass windows. Another great one to check out is the Rotonda de Los Jaliscienses Ilustres, featuring 17 Doric columns dedicated to the city’s favorite authors and revolutionaries. For those who simply want to wander about, Parque Agua Azul offers a great respite from the hustle and bustle of the city.
One of the city’s beloved specialties is the torta ahogada, which is a pork sandwich drowned in broth. If you wish to try some of the best tacos in town, head over to the San Juan de Dios Market.
The city’s rapid transit line, SITEUR, provides intracity and intercity transit services. The main airport of the city is the Guadalajara International, 10 miles south of downtown.
Station Information
Where does the bus leave from in Des Moines?
Main departure station: Diversity Insurance Inc
Most buses depart from the main station in Des Moines.
All bus stations in Des Moines:
Diversity Insurance Inc
Where does the bus arrive in Guadalajara?

Image credit: Elmerhomerochombo
Link to image attributionMain arrival station: Central de Autobuses
The Central de Autobuses is the center of intercity bus transportation in Guadalajara. The large station is located slightly southeast of the city center, but there are several hotels in the area. The station's spacious building includes waiting areas and amenities such as dining areas, vending machines, public restrooms, and ATMs. Many different bus lines, including Tornado Bus and Turimex, operate from the Central de Autobuses. For those arriving in Guadalajara, taxis regularly line up outside the station to deliver you to your final destination in the city.
All bus stations in Guadalajara:
Central de Autobuses
Get around town with Moovit
Need a return trip from Guadalajara to Des Moines?
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