Cheap bus tickets from Des Moines to Port Saint Lucie
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Des Moines to Port Saint Lucie Bus Schedule
Bus from Des Moines to Port Saint Lucie: Journey Information
There are 2 intercity buses per day from Des Moines to Port Saint Lucie. Traveling by bus from Des Moines to Port Saint Lucie usually takes around 53 hours and 34 minutes, but the fastest FlixBus US bus can make the trip in 38 hours and 55 minutes.
| Distance | 1242 mi (1999 km) |
| Shortest duration | 38h 55m |
| Cheapest price | $227.24 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Des Moines to Port Saint Lucie?
There is one intercity bus company available to search and book on Wanderu that operates from Des Moines to Port Saint Lucie. FlixBus US is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 2 | 2d 5h 34m | $301.65 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 2 trips per day from Des Moines to Port Saint Lucie, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Des Moines to Port Saint Lucie
The bus takes an average of 53 hours and 34 minutes to cover the 1242 miles from Des Moines to Port Saint Lucie. However, the fastest bus only takes 38 hours and 55 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
The first bus leaves at 12:00pm and the last bus leaves at 11:00pm. To see the times for all buses from Des Moines to Port Saint Lucie, enter your specific travel dates in the search bar.
City Information
Des Moines

Image credit: Unsplash
Des Moines is the capital city of Iowa and the most populous city in the state. It has been named the third-largest insurance capital in the world because of its relevance in the US insurance industry. Des Moines is home to historic landmarks, especially in the East Village area. These include the gold-domed Iowa State Capitol building. Art lovers can visit the Des Moines Art Center, which has notable contemporary collections, and the Pappajohn Sculpture Park, a pedestrian space with public attractions. Des Moines also has spots for outdoor adventures, like the Blank Park Zoo, Greater Des Moines Botanical Garden, and Living History Farms.
Des Moines offers diverse places for entertainment, like the Praire Meadows Casino, Racetrack & Hotel, and the Salisbury House & Gardens, a concert venue in a 1920s manor. In the heart of the city is Downtown Des Moines, which has different attractions and entertainment venues, festivals and concerts, shopping spots, sports teams, restaurants, bars, and breweries.
It's very easy to access Des Moines when you're traveling by bus. Over a hundred neighboring cities offer bus lines to the city, powered by companies like Jefferson Lines, Tornado Bus, Burlington Trailways, and El Expreso Bus. The Des Moines Area Regional Transit Authority also provides bus routes throughout the city.
Port Saint Lucie

Image credit: Unsplash

Image credit: Unsplash

Image credit: Unsplash
Map out a Florida vacation and it will most probably lead you to Port Saint Lucie. Situated on the Atlantic Ocean coastline of southern Florida, the city includes long ribbons of pristine sand beaches that are an ideal escape from it all.
Head inland, and you'll find a heart ringed by stunning waterways and roughly 20,000 acres of a nature reserve that are just waiting to be discovered. There are various opportunities to try your luck on a fishing adventure, strike out with a rucksack on a day's hike, or ride horses at full gallop in the shallows. Should you prefer, there's also ample opportunity to take to the saddle of a mountain bike to raise the heart rate or enjoy a sedate round of golf at PGA-level facilities.
Neatly positioned between Miami to the south and Orlando to the north, Port Saint Lucie makes for a great way to break up a journey. Buses make frequent arrivals at Port Saint Lucie Service Plaza at Florida Turnpike Mile 144, just two miles from the city center, as well as at 2031 SW Gatlin Blvd and La Bonita.
The ride to Orlando or Miami will take around 3.5 hours, while if you choose, it's possible to head as far afield as Philadelphia, too.
Station Information
Where does the bus leave from in Des Moines?
Main departure station: Bus Station - 1501 2nd St
Most buses depart from the main station in Des Moines.
All bus stations in Des Moines:
Bus Station - 1501 2nd St
Where does the bus arrive in Port Saint Lucie?
Main arrival station: Prt St Lucie (Park & Ride)
All buses from Des Moines arrive at one main station in Port Saint Lucie.
All bus stations in Port Saint Lucie:
Prt St Lucie (Park & Ride)
Get around town with Moovit
Need a return trip from Port Saint Lucie to Des Moines?
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