Cheap bus tickets from Columbus to Knoxville
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Bus from Columbus to Knoxville: Journey Information
There are 3 intercity buses per day from Columbus to Knoxville. Traveling by bus from Columbus to Knoxville usually takes around 15 hours and 36 minutes, but the fastest FlixBus US bus can make the trip in 9 hours and 25 minutes.
Distance | 281 mi (452 km) |
Shortest duration | 9h 25m |
Cheapest price | $52.47 |
Most frequent service | Greyhound |
Bus lines | 2 |

What bus companies travel from Columbus to Knoxville?
There are two bus lines that have daily service from Columbus to Knoxville that you can compare and book on Wanderu. Of these two carriers, Greyhound usually offers more choice, with 2 scheduled trips per day.
Bus | Daily Trips | Avg. Time | Avg. Price |
---|---|---|---|
FlixBus US | 2 | 9h 34m | $119.29 |
Greyhound | 2 | 15h 46m | $69.11 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 2 trips per day from Columbus to Knoxville, and the average ticket for this route costs only .
Greyhound is the largest nationwide bus carrier in the United States, offering cheap, safe and reliable service across the country. Greyhound has become a household name, serving over 16 million passengers per year with daily trips to over 2,400 destinations. Greyhound performs about 2 bus trips from Columbus to Knoxville every day, with the average journey taking around 15 hours and 46 minutes to complete. Bus tickets for Greyhound trips to Knoxville usually start from $52.
Frequently asked questions about traveling by bus from Columbus to Knoxville
The bus takes an average of 15 hours and 36 minutes to cover the 281 miles from Columbus to Knoxville. However, the fastest bus only takes 9 hours and 25 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Tuesday is usually the day of the week when buses are busiest. If you are planning to travel on a Tuesday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Wednesday is typically the least busy day for bus travel on this route. If you're looking for some extra space on the bus, traveling mid-week is your best bet.
The first bus leaves at 12:00am and the last bus leaves at 5:00am. To see the times for all buses from Columbus to Knoxville, enter your specific travel dates in the search bar.
City Information
Columbus



Brimming with life and cultural events, Columbus is the affordable destination of your dreams! Featuring a budding art scene, Columbus attracts art lovers through the exhibitions at the Columbus Museum of Arts where children and adults alike can indulge in thought-provoking artworks. Fans of sports should not miss out on a baseball game at Huntington Park, which offers reasonably-priced tickets; it is also rarely crowded. For those who simply want to stroll about, the German Village offers a quaint and scenic view rarely seen elsewhere.
As the sun goes down, dig deeper into the German heritage of Columbus by enjoying a traditional schnitzel dish at the Schmidt's Restaurant and Sausage Haus. When you are looking for a quick snack, Bodega serves some of the best sandwiches in town, and there are up to 47 varieties of craft beers for you to choose from.
Columbus’ busiest bus station is located on E Town St., and it offers intercity bus trips to Cleveland, Chicago, New York and many other cities. The Columbus Union Station was the first union station ever built, and it’s served by Amtrak’s Lake Shore Limited and Capitol Limited train lines. The local airport, the John Glenn Columbus International Airport, is located on the east side of the city, 6 miles east of Downtown. It provides access to 31 other airports.
Station Information
Where does the bus leave from in Columbus?
Main departure station: Columbus (E Mound St)
Buses to Knoxville leave from 3 stations in Columbus.
All bus stations in Columbus:
Columbus (E Mound St)
100 E Rich St
Ohio State University
Where does the bus arrive in Knoxville?
Main arrival station: Knoxville Bus Station
All buses from Columbus arrive at one main station in Knoxville.
All bus stations in Knoxville:
Knoxville Bus Station
Get around town with Moovit
Need a return trip from Knoxville to Columbus?
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