|Shortest Duration||7h 10m|
|Trips per day||2|
Book Greyhound from Columbus to Knoxville from $62.00. There are 2 trips per day offered by Greyhound from Columbus to Knoxville and you can expect on average to pay $78.22 for a Greyhound ticket to Knoxville. In Columbus, Greyhound departs to Knoxville from Bus Terminal - 111 E Town St, In Knoxville, Greyhound arrives at Bus Terminal - 100 E Magnolia Ave,
An average trip on Greyhound from Columbus to Knoxville takes 8 hours and 42 minutes, while the fastest available Greyhound trip will get you to Knoxville in 7 hours and 10 minutes,
On weekends, Greyhound offers 3 trips per day. A one way ticket costs $79.03 for a weekend trip to Knoxville.