Cheap bus tickets from Florence to Key Largo
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Florence to Key Largo Bus Schedule
Bus from Florence to Key Largo: Journey Information
There are 2 intercity buses per day from Florence to Key Largo. Traveling by bus from Florence to Key Largo usually takes around 23 hours and 37 minutes, but the fastest FlixBus US bus can make the trip in 19 hours and 30 minutes.
| Distance | 631 mi (1015 km) |
| Shortest duration | 19h 30m |
| Cheapest price | $94.96 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Florence to Key Largo?
There is one intercity bus company available to search and book on Wanderu that operates from Florence to Key Largo. FlixBus US is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 2 | 23h 37m | $119.03 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 2 trips per day from Florence to Key Largo, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Florence to Key Largo
The bus takes an average of 23 hours and 37 minutes to cover the 631 miles from Florence to Key Largo. However, the fastest bus only takes 19 hours and 30 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Sunday tends to be the busiest day for buses, as many passengers take the bus to Key Largo at the end of the week. If you are planning to travel on a Sunday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Friday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Friday ticket is the way to go.
The first bus leaves at 12:00am and the last bus leaves at 4:00pm. To see the times for all buses from Florence to Key Largo, enter your specific travel dates in the search bar.
City Information
Florence
Florence is a hidden gem in the northeast of South Carolina. Though best known for its history as a significant railway hub, Florence is a modern city with activities and sights to fill a weekend getaway or a longer vacation.
Every November, Florence goes nuts during the SC Pecan Music and Food Festival, an event hosted downtown to celebrate the beloved pecan. If you're in town during the festival, check out the car show, live music, half marathon, and other associated events to get to know Florence locals and culture.
Florence is a year-round destination for outdoor recreation. Golf is a favorite among Florence residents, so upgrade from mini-golf and try the real thing. Traces Golf Club welcomes golfers of all skill levels, don't worry. Don't leave Florence without spending a day at Lynches River County Park, the starting point of the 66-mile South Carolina Revolutionary Rivers Trail. You can kayak or canoe throughout the county, following the swampy path that allowed American patriots to evade British troops in the American Revolution.
Florence Regional Airport operates limited flights to connect to Charlotte, but most paths to Florence involve some kind of ground travel. Amtrak's Palmetto and Silver Service trains stop in Florence, with connections to New York and Washington to the north and Orlando and Miami to the south. Greyhound and Southeastern Stages offer intercity bus service to Florence that connects the city to other destinations throughout the South.
Station Information
Where does the bus leave from in Florence?
Main departure station: Florence
Florence has two bus stations with service to Key Largo.
All bus stations in Florence:
Florence
2301 W Lucas St (TA Gas Station)
Where does the bus arrive in Key Largo?
Main arrival station: 99501 Overseas Hwy
All buses from Florence arrive at one main station in Key Largo.
All bus stations in Key Largo:
99501 Overseas Hwy
Get around town with Moovit
Need a return trip from Key Largo to Florence?
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