5.0
Pros: Location for PICKUP and dropoff both worked easily for me. Very punctual. Smooth ride. Experienced drivers. Cons: Driver might check with clients regarding temperature in the van. Tips: Decent price for safe easy connection.
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There are usually 2 daily train trips available from Saint Paul to La Crosse.
Bus | Train | |
|---|---|---|
Avg. Price | Avg. Price$29.00 | Avg. Price$28.11 |
Daily Trips | Daily Trips5 | Daily Trips2 |
Duration | Duration4h 39m | Duration2h 37m |
There are 4 intercity buses per day from St Paul to La Crosse. Traveling by bus from St Paul to La Crosse usually takes around 4 hours and 25 minutes, but the fastest Jefferson Lines bus can make the trip in 3 hours,
| Distance | 121 mi (195 km) |
| Shortest duration | 3h 0m |
| Cheapest price | $29.00 |
| Trips per day | 2 |
| Most frequent service | Jefferson Lines |
| Bus lines | 1 |

Average score for buses from Saint Paul to La Crosse
(Based on 1 ratings and reviews)
5.0
Pros: Location for PICKUP and dropoff both worked easily for me. Very punctual. Smooth ride. Experienced drivers. Cons: Driver might check with clients regarding temperature in the van. Tips: Decent price for safe easy connection.
There is one intercity bus company available to search and book on Wanderu that operates from St Paul to La Crosse. Jefferson Lines connects the two cities by bus, it offers multiple scheduled buses per day for you to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| Jefferson Lines | 4 | 4h 25m | $29.00 |
Book Jefferson Lines from Saint Paul to La Crosse from $29. There are 4 trips per day offered by Jefferson Lines from St Paul to La Crosse and you can expect on average to pay for a Jefferson Lines ticket to La Crosse. In Saint Paul, Jefferson Lines departs to La Crosse from Union Depot . In La Crosse, Jefferson Lines arrives at 314 Jay St and one other station.
An average trip on Jefferson Lines from Saint Paul to La Crosse takes 4 hours and 25 minutes , while the fastest available Jefferson Lines trip will get you to La Crosse in 3 hours and 0 minutes .
On weekends, Jefferson Lines offers 3 trips per day. A one way ticket costs for a weekend trip to La Crosse.
The bus takes an average of 4 hours and 25 minutes to cover the 121 miles from St Paul to La Crosse. However, the fastest bus only takes 3 hours. In other words, you'll have plenty of time to rest and relax on the road. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Friday is the busiest travel day for buses as people head from St Paul to La Crosse for the weekend. If you are planning to travel on a Friday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Sunday is typically the least busy day for bus travel on this route. If you are looking for less crowded buses to La Crosse, book your ticket for the last day of the week.
The first bus leaves at 9:00am and the last bus leaves at 11:00am. To see the times for all buses from St Paul to La Crosse, enter your specific travel dates in the search bar.
There are 4 scheduled buses that travel from St Paul to La Crosse every day, so you have a decent number of options to choose from. This includes 2 direct buses, where you can stay on the same bus without having to transfer to a connecting bus at any point during your trip.
Need more travel options? Consider taking the train from St Paul to La Crosse; ticket prices start at $18.00.

Image credit: Unsplash

Image credit: Unsplash

Image credit: Unsplash
Saint Paul is the capital of Minnesota, and is one of the Twin Cities, along with its neighbor across the Mississippi River, Minneapolis. As the seat of Minnesota's government, Saint Paul offers historic and cultural attractions which represent both the state and the American Midwest as a whole.
For a comprehensive introduction to the region's history, start your trip at the Minnesota History Center, just down the street from the grounds of the State Capitol building. There are museums in Saint Paul for all types of interests, including the Science Museum of Minnesota and the Schubert Club Musical Instrument Museum. For an extra dash of Saint Paul history, take a stroll down Summit Avenue, a stylish street of drool-worthy Victorian houses and mansions, including the home of F. Scott Fitzgerald.
If you're brave enough to visit Saint Paul during the freezing winters, you'll be rewarded with the Saint Paul Winter Carnival, a yearly event where you can explore ice palaces, watch live ice sculpting, and compete in city-wide scavenger hunts. Saint Paul is also one of the country's best cities for craft beer, so save time to taste some local ales or even brew your own beer at Vine Park Brewing Co.
Saint Paul is a hub for travel in the Midwest thanks in part to Amtrak's Empire Builder train service which stops at Saint Paul Union Depot. Bus service from stations throughout town and nearby Minneapolis–Saint Paul International Airport make it easy to travel to and from this saintly city.
A busy college town blessed with lush and beautiful green zones, La Crosse is one of the best places to just chill out and unwind. The city's star attraction is the Grandad Bluff, which offers a panoramic view of the entire city and the Mississippi River. Hiking up the hill will certainly be a challenge, but the view from the top makes it all worthwhile. While staying in the city, don't miss out on the chance to go on a cruise aboard the La Crosse Queen, a replica paddle steamer, and unwind while enjoying the sunset. For some family fun, head over to the Children's Museum of La Crosse.
La Crosse does have a pretty reputable food scene, with a strong focus on beers and cheese curds. For an upscale dining experience with the best local dishes, The Waterfront Restaurant & Tavern is a local favorite that has a stellar reputation. Or head to the Dublin Square Irish Pub & Eatery for a combination of good foods and drinks.
La Crosse is easily accessible by bus or train, and regional flights operate out of the La Crosse Municipal Airport.

Image credit: David Wilson
Link to image attributionLocated right on the banks of the Mississippi River in Saint Paul’s Lowertown neighborhood, Union Depot has a remarkable history dating back to 1881. It remains the major transport hub of Saint Paul, as well as the designated station for Amtrak service in the Twin Cities. Besides the long-haul Empire Builder train, the station serves Jefferson Lines and Greyhound intercity buses and connects to local public transit. Within the Union Depot complex, you’ll find a coffee shop, restaurant, bike shop, rental car agency, and can even join a public tour to admire the architecture and learn about the station’s storied past.
Union Depot
Buses to La Crosse stop at Jay Street in front of the Grand River Station. The aptly-named grand building features arching ceilings, marble decoration, and amenities like seating and vending machines inside. The station is conveniently located in downtown La Crosse with easy access to surrounding hotels, restaurants, and a rental car agency across the street. Bus lines, including Greyhound and Jefferson Lines, connect La Crosse to Minneapolis, Milwaukee, Chicago, and beyond.
314 Jay St
University of WI

With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.