Cheap bus tickets from Florence to San Francisco
Find and compare the best ground travel options in one place.
Millions of travelers trust Wanderu every year to get:
Lowest Prices
We find the cheapest bus & train tickets, so you can wander for less.
Best Travel Options
We partner with 500+ carriers to bring you the most bus & train options.
Quick & Easy Booking
Book trips quickly with a simple, hassle-free checkout – online & on our app.
Fast Customer Support
We don’t monkey around. We respond within minutes to help you out.
See what travelers are saying about Wanderu:
Florence to San Francisco Bus Schedule
Bus from Florence to San Francisco: Journey Information
There are 2 intercity buses per day from Florence to San Francisco. Traveling by bus from Florence to San Francisco usually takes around 78 hours and 25 minutes, but the fastest FlixBus US bus can make the trip in 75 hours and 30 minutes.
| Distance | 2377 mi (3826 km) |
| Shortest duration | 75h 30m |
| Cheapest price | $232.94 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |

What bus companies travel from Florence to San Francisco?
There is one intercity bus company available to search and book on Wanderu that operates from Florence to San Francisco. FlixBus US is the one bus line that serves this route. Although it's the sole option, there are a couple of different scheduled times to choose from.
| Bus | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 2 | 3d 6h 25m | $339.31 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 2 trips per day from Florence to San Francisco, and the average ticket for this route costs only .
Frequently asked questions about traveling by bus from Florence to San Francisco
The bus takes an average of 78 hours and 25 minutes to cover the 2377 miles from Florence to San Francisco. However, the fastest bus only takes 75 hours and 30 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
Saturday is usually the day when buses are busiest, as many travelers take the bus to enjoy the weekend in San Francisco. If you are planning to travel on a Saturday, you should make sure to book tickets well in advance as they may sell out.
On the other hand, Tuesday is typically the least busy day for bus travel on this route. If you’re looking for a little extra space, a Tuesday ticket is the way to go.
The first bus leaves at 12:00am and the last bus leaves at 12:00am. To see the times for all buses from Florence to San Francisco, enter your specific travel dates in the search bar.
There are usually only 2 buses per day from Florence to San Francisco. However, neither bus offers direct service, so you will have to get off your original vehicle to transfer buses during the trip.
Need more travel options? Consider taking the train from Florence, SC to San Francisco, CA; ticket prices start at $748.00.
City Information
Florence
Florence is a hidden gem in the northeast of South Carolina. Though best known for its history as a significant railway hub, Florence is a modern city with activities and sights to fill a weekend getaway or a longer vacation.
Every November, Florence goes nuts during the SC Pecan Music and Food Festival, an event hosted downtown to celebrate the beloved pecan. If you're in town during the festival, check out the car show, live music, half marathon, and other associated events to get to know Florence locals and culture.
Florence is a year-round destination for outdoor recreation. Golf is a favorite among Florence residents, so upgrade from mini-golf and try the real thing. Traces Golf Club welcomes golfers of all skill levels, don't worry. Don't leave Florence without spending a day at Lynches River County Park, the starting point of the 66-mile South Carolina Revolutionary Rivers Trail. You can kayak or canoe throughout the county, following the swampy path that allowed American patriots to evade British troops in the American Revolution.
Florence Regional Airport operates limited flights to connect to Charlotte, but most paths to Florence involve some kind of ground travel. Amtrak's Palmetto and Silver Service trains stop in Florence, with connections to New York and Washington to the north and Orlando and Miami to the south. Greyhound and Southeastern Stages offer intercity bus service to Florence that connects the city to other destinations throughout the South.
San Francisco

Image credit: Unsplash

Image credit: Unsplash

Image credit: Unsplash
Located in the heart of Northern California's Bay Area, San Francisco is a geographically small but culturally huge city known for its historic cable cars, active waterfront, and the eclectic mix of hippies and techies who call it home. While it might be one of the most expensive U.S. cities to live in, San Fran can actually be very cheap to visit, and there is no shortage of unique sights to see.
If the city's omnipresent fog (nicknamed "Karl the Fog" by locals) takes a break, the best views and Instagram photo ops of the world-famous Golden Gate Bridge are found in Golden Gate Park. Stroll through the oldest Chinatown in North America to find the perfect dim sum, or if you and your boo prefer a little Full House moment, try a romantic picnic at Alamo Square Park in front of the Victorian "Painted Ladies." After all, San Francisco is one of the best vacation destinations for couples.
Since the city is condensed onto a small peninsula, exploring by bike is an efficient and scenic way to get around. When you’re ready to travel beyond city limits, San Francisco is a convenient hub for trips throughout Northern California. It's actually the first stop on Wanderu's West Coast Wine Tour, with the next stop, obviously, in Napa Valley. Whether traveling by bus, train, or through either of the two nearby airports, San Francisco is a can't-miss destination.
Station Information
Where does the bus leave from in Florence?
Main departure station: 2301 W Lucas St (TA Gas Station)
Most buses depart from the main station in Florence.
All bus stations in Florence:
2301 W Lucas St (TA Gas Station)
Where does the bus arrive in San Francisco?
Main arrival station: Salesforce Transit Center
These are the two stations where buses may stop when they arrive in San Francisco.
All bus stations in San Francisco:
Salesforce Transit Center
Caltrain Station - 5th & Townsend St
Get around town with Moovit
Need a return trip from San Francisco to Florence?
Search Bus Tickets
Wanderu is the simplest way to book bus and train travel.
With just a quick search on Wanderu, you can compare bus and train schedules and prices from hundreds of travel companies in one convenient place to find the trip that works best for you. Wanderu’s simple checkout process makes it easy to book cheap bus and train tickets hassle-free. Most importantly, as Wanderu is an official partner of all leading bus and train companies, we always have the best bus and train deals out there.
- Bus Tickets
- United States
- California
- San Francisco
- Florence, SC to San Francisco, CA






