Cheap bus tickets from Florence, SC to Cincinnati, OH
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Bus from Florence, SC to Cincinnati, OH: Journey Information
There is one daily bus from Florence, SC to Cincinnati, OH. Traveling by bus from Florence, SC to Cincinnati, OH usually takes around 32 hours and 11 minutes, but the fastest FlixBus US bus can make the trip in 31 hours and 35 minutes.
| Distance | 429 mi (691 km) |
| Shortest duration | 31h 35m |
| Cheapest price | $107.44 |
| Trips per day | 0 |
| Most frequent service | FlixBus US |
| Bus lines | 1 |
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Florence to Cincinnati Bus Schedule
Is it better to travel by bus or train from Florence to Cincinnati?
There are usually 1 daily train trips available from Florence, SC to Cincinnati, OH.
Bus | Train | |
|---|---|---|
Avg. Price | Avg. Price$183.98Cheaper | Avg. Price$421.00 |
Daily Trips | Daily Trips1 | Daily Trips1 |
Duration | Duration32h 11m | Duration27h 39mFaster |

There are several bus options that can take you from Florence to Cincinnati:
See more detailsHow much is a bus ticket from Florence, SC to Cincinnati, OH?
Bus tickets for a trip from Florence, SC to Cincinnati, OH cost $179.21 on average. Bus tickets on this route can be a bit expensive due to the length of the trip. But even with a higher price tag, taking the bus is often more affordable than flying to Cincinnati, OH. If you book your trip ahead of time using Wanderu, you can easily find bus tickets at or below this price.
Average bus ticket prices from Florence, SC to Cincinnati, OH by travel date
If you're planning to travel by bus from Florence, SC to Cincinnati, OH in the next month, the average ticket price is expected to range from $137 to $154. The cheapest bus tickets available in the next few weeks are for trips departing on August 23, 2026. If you’re looking to travel to Cincinnati, OH this week, bus tickets are available starting at $137.
Prices as travel date approaches
Most bus companies charge higher ticket prices closer to the date of travel, so it’s a good idea to buy your bus tickets as early as possible. To save money on bus tickets and ensure availability, it's always best to book in advance.
What bus companies travel from Florence to Cincinnati?
There are multiple buses that travel from Florence to Cincinnati, including FlixBus US. Here is what you should know about the 1 most popular bus lines:
| BUS | Daily Trips | Avg. Time | Avg. Price |
|---|---|---|---|
| FlixBus US | 1 | 32h 11m | $183.98 |
FlixBus US is the American branch of German bus company FlixBus, known for providing sustainable, affordable, and modern bus travel. The company offers cheap bus tickets to popular urban destinations throughout the United States. FlixBus US buses include many amenities, including comfortable seats, free WiFi, power outlets at every seat, and an online portal for free entertainment. On average, FlixBus US operates 1 trips per day from Florence, SC to Cincinnati, OH, and the average ticket for this route costs only $183.98.






Frequently asked questions about traveling by bus from Florence to Cincinnati
There is usually only one bus per day from Florence, SC to Cincinnati, OH. However, it is not a direct bus, so you will have to get off your original vehicle to change buses during the trip. Need more travel options? Consider taking the train from Florence, SC to Cincinnati, OH; ticket prices start at $421.
TRIPS PER DAY
1
DIRECT TRIPS
0
The bus takes an average of 32 hours and 11 minutes to cover the 429 miles from Florence, SC to Cincinnati, OH. However, the fastest bus only takes 31 hours and 35 minutes. It’s definitely on the longer side, so plan to get comfortable for a long road trip. Keep in mind that your actual bus may arrive earlier or later than scheduled, depending on whether there is more or less traffic than usual.
DISTANCE (MI)
429
DISTANCE (KM)
691
There is usually only one bus per day from Florence, SC to Cincinnati, OH. It leaves the station in Florence, SC at 5:45am each day. The time might vary for specific dates, so be sure to search on Wanderu for the most up-to-date information.
EARLIEST BUS
12:05am
LATEST BUS
5:45am
Sunday tends to be the busiest day for buses, as many passengers take the bus to Cincinnati, OH at the end of the week. If you are planning to travel on a Sunday, you should make sure to book tickets well in advance as they may sell out. On the other hand, Wednesday is typically the least busy day for bus travel on this route. If you're looking for some extra space on the bus, traveling mid-week is your best bet.
MOST CROWDED
Sunday
LEAST CROWDED
Wednesday
City Information
Florence, SC
Florence is a hidden gem in the northeast of South Carolina. Though best known for its history as a significant railway hub, Florence is a modern city with activities and sights to fill a weekend getaway or a longer vacation.
Every November, Florence goes nuts during the SC Pecan Music and Food Festival, an event hosted downtown to celebrate the beloved pecan. If you're in town during the festival, check out the car show, live music, half marathon, and other associated events to get to know Florence locals and culture.
Florence is a year-round destination for outdoor recreation. Golf is a favorite among Florence residents, so upgrade from mini-golf and try the real thing. Traces Golf Club welcomes golfers of all skill levels, don't worry. Don't leave Florence without spending a day at Lynches River County Park, the starting point of the 66-mile South Carolina Revolutionary Rivers Trail. You can kayak or canoe throughout the county, following the swampy path that allowed American patriots to evade British troops in the American Revolution.
Florence Regional Airport operates limited flights to connect to Charlotte, but most paths to Florence involve some kind of ground travel. Amtrak's Palmetto and Silver Service trains stop in Florence, with connections to New York and Washington to the north and Orlando and Miami to the south. Greyhound and Southeastern Stages offer intercity bus service to Florence that connects the city to other destinations throughout the South.
Cincinnati, OH



A city famous for its idyllic beauty and quaint quarters, Cincinnati is the destination for tourists who wish to stay away from a large crowd. On a bright sunny day in Cincinnati, head over to Eden Park. Encompassing over 183 acres of green space and tree groves, the park lives up to its name, and there are some scenic ponds where you can unwind as well as take a few amazing pictures. Spring Grove Cemetery & Arboretum might sound like a scary place to visit, but its tranquility and amazing landscape design, which was ahead of its time, will make it worth the while to check it out. For those who still crave some liveliness, watching a game at the Great American Ball Park, home of the oldest professional baseball team, the Cincinnati Reds, will be an unforgettable experience.
Cincinnati features a very diverse food scene in spite of its German roots. If you are looking to try out some refreshing Mediterranean dishes, head over to Abigail Street, one of the local favorites. For authentic German dishes, the door at Mecklenburg Gardens welcomes you.
There’s not a central bus station in the city, as each of the different bus carriers serving Cincinnati operates out of a different location. The principal Amtrak train station is the Union Terminal on Western Ave. Cincinnati is served by Amtrak’s Cardinal line. The city’s main airport is the Cincinnati/Northern Kentucky International Airport, which is located in Hebron, Kentucky.
Station Information
Where does the bus leave from in Florence?
Main departure station: 2301 W Lucas St (TA Gas Station)
Most buses depart from the main station in Florence, SC.
All bus stations in Florence:
- 2301 W Lucas St (TA Gas Station)
Where does the bus arrive in Cincinnati?
Main arrival station: University of Cincinnati - 2985 Short Vine St
All buses from Florence, SC arrive at one main station in Cincinnati, OH.
All bus stations in Cincinnati:
- University of Cincinnati - 2985 Short Vine St
Need a return trip from Cincinnati to Florence?
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